IndraLab

Statements

USP3 inhibits IFIH1. 3 / 3
| 3
reach
"While the deubiquitinase USP3 inhibits MDA5 as well as RIG-I, it is thought that this may be due to USP3 directly binding the MDA5 CARD domain to prevent RNA filamentation (284)."
31379819
reach
"USP3 and USP21 inhibit MDA5 function via deubiquitination XREF_BIBR, XREF_BIBR, and proteins such as dihydroxyacetone kinase (DAK), Atg5-Atg-12, NLRC5, and TRIM13 interact with and inhibit MDA5 XREF_BIBR, XREF_BIBR - XREF_BIBR."
31827068
reach
"In addition, ubiquitin-specific protease 3 (USP3), a deubiquitinase, was reported to bind to MDA5, remove K63-polyubiquitin chains on the N-terminal CARDs, and then inhibit MDA5 activity [168]."
35619184