IndraLab

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"We next asked whether reduction in caspase cleavage modulates Ataxin-3 protein toxicity."

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"In a Drosophila model of SCA3, mutation of proposed caspase cleavage sites in ATXN3 dramatically reduces production of polyQ enriched fragments [XREF_BIBR] and ameliorates degeneration caused by polyQ expanded ATXN3."