Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PSMD14 inhibits RNF8. 2 / 3

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"BRCC36 and POH1 antagonize the actions of RNF8 and RNF168, hydrolyzing the K63 linkages that promote 53BP1 recruitment."

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"POH1 is localized to sites of DSBs and can directly antagonize RNF8/RNF168, which collaborate to deposit K63-linked polyubiquitin chains at H2A-type histones in response to damage [129]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...