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HCN4 activates pyraclofos. 4 / 4
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"Within this range of membrane potentials, mode shifts in HCN4 cause the voltage-dependent hysteresis that could induce the alternations between firing and nonfiring (Figure 5A and 5B)."
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"In the case of HCN channels, increased cAMP binds to CNBD of HCN4, which increases the open state of HCN channels in response to voltage."
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"Since cholesterol regulates a variety of ion channels important for cardiac function2938394041, including rabbit HCN4 in which cholesterol depletion had previously been shown to modulate voltage dependence of activation and the kinetics of deactivation28, we systematically examined the role of cholesterol in regulating the 3 human cardiac isoforms of HCN channels."
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"The recent data and simulations by Hoekstra et al. (2021) report of a small fully-activated HCN4-specific current, insufficient by itself to drive the membrane voltage from the MDP to the take-off pot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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