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KCNQ1ot1 inhibits KCNQ1. 1 / 1

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"Intriguing examples are the p15AS (p15 antisense transcript), which is expressed in antisense orientation to the cyclin dependent kinase inhibitor p15 and controls its silencing by heterochromatin formation in a DICER dependent manner, and the KCNQ1 antisense transcripts (KCNQ1ot1) which represses KCNQ1 by recruiting the H3K9 histone methyltransferase G9a and the PRC2 complex increasing the level of H3K9me3 and H3K27me3 in cis to its locus."

26617633

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KCNQ1ot1 inhibits KCNQ1. 1 / 1

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