IndraLab

Statements

ITGB1 binds THBS1. 9 / 10
1 | 2 6
biogrid
No evidence text available
14963009
sparser
"Transcriptomic and proteomic profiling confirmed enrichment of the PI3K/Akt/mTOR pathway in HFpEF hearts, and co-immunoprecipitation demonstrated that Thbs1 physically interacts with ITGB1, suggesting that ITGB1 functions as a receptor linking Thbs1 to PI3K/Akt/mTOR activation."
41623478
sparser
"spaCI not only reveals L–R interactions that are not obvious in the original, sparse seqFISH+ data, but also identifies significant interactions between fibroblast and tumours in with strong L–R interactions such as the THBS1–ITGB1 interaction in lung cancer tissue."
36545790
sparser
"For instance, in ANXA1-CXCR3, THBS1-ITGB1, and ITGB1-CD46 interactions between cancer epithelial and NK cells(Fig.  xref ), ligand expression in cancer cells is significantly lower in the query dataset compared to the reference, regardless of receptor expression levels."
41390348
sparser
"Consistent with previous reports, we found that TSP1 interacts with ITGB1; however, the S93D mutation altered ITGB1 cluster formation."
41594624
sparser
"Our results suggest that enhanced binding of the TSP1 S93D to ITGB1 interferes with FAK activation, leading to reduced PXN phosphorylation and, consequently, impaired cell migration."
41594624
reach
"Many PTGs were involved in biological processes related to follicular development and ovulation, such as the regulation of progesterone biosynthesis, estrogen metabolism, negative regulation of cell proliferation, ITGA3–ITGB1–THBS1 complex formation, cellular response to transforming growth factor beta stimulus, meiotic cell cycle, and steroid catabolic process (p < 0.05) (Fig. 5A)."
34795345
reach
"From the Sankey plot, we observed prevalent interactions between THBS1/THBS2 and ITGB1 [31], with upstream TFs including SMAD3, JUN and EST1."
36545790
sparser
"Cytoskeletal rearrangements could promote the formation of filopodia, which was shown to be associated with β1 integrin-dependent adhesion to intact THBS1 [ 29 ]."
30439539