IndraLab

Statements

STAMBP decreases the amount of IL1B. 6 / 6
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"Our group previously demonstrated a functional relationship between STAMBP and another inflammasome protein NLRP7, whereby STAMBP knockdown enhanced NLRP7 degradation and decreased IL-1β release in differentiated THP-1 macrophages (20)."
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"This exaggerated inflammatory response was dependent on IL-1beta signaling, and STAMBP knockout directly increased release of IL-1beta with TLR ligation."
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"In a monocyte cell line, genetic knockout of STAMBP increases IL-1β secretion and increases subsequent IL-1β-driven cytokine and chemokine gene expression."
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"Moreover, STAMBP deficiency increases the IL-1β gene expression and cytokine level in response to LPS, and showed an increase in ASC speck and active caspase-1 levels."
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"In this study, we demonstrate STAMBP-mediated ubiquitination of NLRP3 to provide a non- degradative signal, and STAMBP knockout increased IL-1β secretion in undifferentiated THP-1 monocytes (Fig. 2)."
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"3.2 STAMBP knockout increases IL-1beta secretion in THP-1 monocytes after endotoxin.."
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