IndraLab

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USP3 inhibits UIMC1. 2 / 2

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"Overexpression of USP3, while having no effect on retention of RNF8 at DSBs, abolished the IR induced focus formation of RNF168, RAP80, and 53BP1, indicating that it de-ubiquitylates RNF8 targeted substrates."

23847653

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"53BP1 and RAP80 foci are also negatively regulated by USP3 catalytic activity [18,110,132,135,136]."

32708614

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IndraLab

Statements

USP3 inhibits UIMC1. 2 / 2

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