IndraLab

Statements

USP4 inhibits TNF. 9 / 11
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"USP4 has been shown to inhibit TNFα-induced cancer cell migration and breast cancer cell growth through upregulation of programmed cell death 4 (PCD4) [31] ."
29864528
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"In another study, USP4 was shown to negatively regulate TNF-induced NF-κB activation by de-ubiquitinating TRAF2 [114] ."
22119011
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"USP4 was identified by studies to negatively regulate both TNF-alpha- and IL-1beta-induced NF-kappaB activation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Moreover, we found that USP4 targets HDAC2 to downregulate tumor necrosis factor-alpha (TNFalpha)-induced NF-kappaB activation."
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"Notably, USP4 overexpression antagonized OGD/R-induced IL-1β, IL-6, and TNF-α transcriptional levels (Fig. 3A–C)."
35530618
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"Recently, also USP4 was shown to downregulate TNF-induced NF-κB activation in two independent studies."
22119011
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"Consequently, knockdown of USP4 enhanced TNF-induced NF-κB activation."
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"USP4 negatively regulates TNFalpha induced, K63 linked TAK1 polyubiquitination and TAK1 mediated IKK and NF-kappaB activation [XREF_BIBR]."
33138315
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"Additionally, the overexpression of USP4 suppressed the release of microglia activation-induced pro-inflammatory cytokines, including IL-1beta, IL-6, and TNF-alpha."
35530618