IndraLab

Statements

KCNH2 inhibits sotalol. 4 / 4
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"Cellular expression studies showed that the N588K mutation in KCNH2 in these patients reduced binding of sotalol to the I kr channel [XREF_BIBR]."
20126594
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"However, after including the combined stereospecific beta-blocking effect of sotalol (dominated by l-sotalol as shown in Appendix A Fig. S4D) in addition to hERG inhibition effects by racemic dl-sotalol, we were able to reproduce clinical QT interval prolongation [82] by model 2 (compare black and red curves in Fig. 7C)."
34062207
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"18, 19 Wolpert et al, prove that mutations in KCNH2 reduce the affinity of sotalol in I Kr unlike quinidine."
33335610
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"However, many hERG blocking drugs including sotalol are suggested to have a higher affinity for the inactivated channel state [48,66,79]."
34062207