IndraLab

Statements

USP2 inhibits UCP2. 2 / 2
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"Since USP2 stabilizes PGC1α by deubiquitination, USP2 might eliminate mitochondrial ROS by activating the PGC1α–UCP2 axis."
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"Based on this idea, a putative protein digestion mechanism might reduce the excessive accumulation of UCP2 in C2C12 cells.As found in the current study, the inhibition of USP2 interrupts mitochondrial ATP synthesis in myoblasts, leading to defects in proliferation and differentiation [33,42]."
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