IndraLab

Statements

USP11 activates translation. 6 / 6
| 6
reach
"Overexpression of either eIF4B or USP11 significantly enhanced both cap dependent as well as IRES mediated translation in a dose dependent manner."
29483509
reach
"Similarly, the Gartenhaus lab using both pharmacological and genetic approaches, reported that FASN induced S6Kinase signaling to phosphorylate USP11 enhancing its interaction and stability of eIF4B in DLBCL consequently promoting oncogenic translation(11)."
35191952
reach
"Indeed, USP11 was noted to be phosphorylated by S6Kinase that increases its interaction with eIF4B and subsequently enhanced cancer promoting gene translation."
29483509
reach
"USP11 stimulates translation."
29483509
reach
"Ectopic expression of USP11 (W) or USP11 S453D, but not USP11 S453A, enhanced the overall mRNA translation in DLBCLs."
29483509
reach
"We further demonstrated that USP11 activity stabilizes eIF4B protein levels and stimulates oncogenic translation."
29483509