IndraLab

Statements

USP11 activates translation. 8 / 8
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"USP11 stimulates translation."
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"Overexpression of either eIF4B or USP11 significantly enhanced both cap dependent as well as IRES mediated translation in a dose dependent manner."
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"Similarly, the Gartenhaus lab using both pharmacologic and genetic approaches, reported that FASN induced S6Kinase signaling to phosphorylate USP11 enhancing its interaction and stability of eIF4B in DLBCL consequently promoting oncogenic translation (11)."
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"USP11 stabilizes and enhances Eukayotic translation initiation factor 4B (eIF4B) activity and promotes oncogenic translation in diffuse large B cell lymphoma (DLBCL) (34)."
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"Ectopic expression of USP11 (W) or USP11 S453D, but not USP11 S453A, enhanced the overall mRNA translation in DLBCLs."
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"We further demonstrated that USP11 activity stabilizes eIF4B protein levels and stimulates oncogenic translation."
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"Indeed, USP11 was noted to be phosphorylated by S6Kinase that increases its interaction with eIF4B and subsequently enhanced cancer promoting gene translation."
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"Moreover, Qisheng Li et al. have employed functional genomics approaches and HCV model systems to demonstrate the involvement of USP11 in HCV-mediated translation, but the finer details of its regulatory mechanisms remain elusive (93)."
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