IndraLab

Statements

P5091 inhibits USP47. 6 / 6
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"P5091 has been recently reported to also inhibit USP47, one deubiquitinase most closely related to USP7 [27] ."
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"These compounds were found to be highly selective for USP7 in counter-screening against a panel of DUBs including USP10 and USP47, which are also inhibited by P5091."
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"For example, P22077 and P5091 also inhibited USP47 with similar potency [10,77,83,87] ."
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"P5091 is an inhibitor of USP7 and USP47 ( Chauhan et al., 2012; Weinstock et al., 2012 ) and was found to induce apoptosis of multiple myeloma cells resistant to the 20S proteasome inhibitor bortezomi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"P5091 has been shown to inhibit tumor growth by inhibiting USP7 and USP47 and is well tolerated in animals [107] ."
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"However, the commercially available inhibitors for these DUBs had no obvious influence on the SOX2 expression, including b-AP15 (the inhibitor of USP14 and UCHL5), P5091 (the inhibitor of USP7 and USP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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