IndraLab

Statements


EGF binds EGFR and PTK2. 4 / 4
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sparser
"Here we identified SRC-3Δ4 as a signaling adaptor to mediate the interaction between EGFR and FAK and EGF signal transduction in promoting cell migration ( xref )."

sparser
"In this study, we identified SRC-3Δ4 as the missing adaptor protein that bridges the interaction between EGFR and FAK upon EGF stimulation."

sparser
"These results substantiate that SRC-3Δ4 plays a key role in mediating the EGF-induced interaction between EGFR and FAK, and in EGF signal transduction from EGFR to FAK to promote cell migration."

sparser
"Importantly, knockdown of SRC-3Δ4 in MDA-MB231 cells hindered EGF-induced interaction between EGFR and FAK ( xref ), and greatly decreased EGF-stimulated FAK phosphorylation on Y925 ( xref )."