A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

EGF binds EGFR and PTK2. 4 / 4
| 4
sparser
"Here we identified SRC-3Δ4 as a signaling adaptor to mediate the interaction between EGFR and FAK and EGF signal transduction in promoting cell migration ( xref )."
sparser
"These results substantiate that SRC-3Δ4 plays a key role in mediating the EGF-induced interaction between EGFR and FAK, and in EGF signal transduction from EGFR to FAK to promote cell migration."
sparser
"Importantly, knockdown of SRC-3Δ4 in MDA-MB231 cells hindered EGF-induced interaction between EGFR and FAK ( xref ), and greatly decreased EGF-stimulated FAK phosphorylation on Y925 ( xref )."
sparser
"In this study, we identified SRC-3Δ4 as the missing adaptor protein that bridges the interaction between EGFR and FAK upon EGF stimulation."