IndraLab

Statements

CD274 binds USP18. 3 / 3
| 1 2
reach
"USP7, USP22, USP8, USP18, USP9X and USP5 have been demonstrated directly bind with PD-L1 to induce its deubiquitination and stabilization [60, 100–102, 143, 164, 186]."
37658402
sparser
"Additionally, the USP18-PD-L1 complex exhibited a binding free energy of −12.0 kcal/mol and a dissociation constant of 1.6×10 −09 M, further confirming the high stability of the complex."
39334957
sparser
"Moreover, an exhaustive analysis of amino acid residue contacts within both complexes was conducted, with particular attention to the number of contacts between charged polar residues and nonpolar residues, with the ISG15-PD-L1 and USP18-PD-L1 complexes having contact counts of 12 and 24 and 20 and 18, respectively."
39334957