IndraLab

Statements

JOSD1 deubiquitinates JAK2-V617F. 2 / 2
| 2
reach
"JOSD1 deubiquitinates and stabilises mutant JAK2 (JAK2-V617F), and therefore, inactivation of JOSD1 via small molecules led to the degradation of mutant JAK2 in MPNs providing a novel therapeutic approach for the disease [23]."
39284830
reach
"The preferential regulation of oncogenic mutated substrates by DUBs, as previously reported, where USP10 and JOSD1 selectively deubiquitinate FLT-mutants and JAK2-V617F, respectively , is also mirrored in the current study."
40240366