IndraLab

Statements

USP18 inhibits JAK. 5 / 9
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"Taken together, we concluded that USP18 potentiates the anti-HBV activity of IFN-alpha by targeting the JAK and STAT signaling pathway in Hepg2.2.15 cells."
27227879
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"Moreover, USP18 competitively inhibits IFN-alpha and beta-induced JAK and STAT activation [XREF_BIBR] and upregulates epidermal growth factor receptor (EGFR) expression [XREF_BIBR]."
26046984
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"It has been reported that C-terminal region of USP18 (amino acid residue 312-368) competes with Jak1 for interacting with the type I IFN receptor (IFNAR2) and represses downstream Jak and STAT signaling pathway [XREF_BIBR]."
29285303
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"As expected, exogenous USP18 expression significantly inhibited IFN-a-induced Jak and STAT signaling as shown by decreased p-STAT1 levels and ISRE activity."
29285303
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"Suppression of USP18 activated the JAK and STAT signaling pathway as shown by the increased and prolonged expression of phosphorylated signal transducer and activator of transcription 1 (p-STAT1) in combination with enhanced expression of several interferon stimulated genes (ISGs)."
27227879