IndraLab

Statements

USP18 inhibits JAK. 11 / 15
| 11
reach
"In both IFN α/β-treated and untreated USP18-knockdown cells, USP18 negatively regulates the JAK/STAT pathway to amplify and strengthen IFN signalling [ 43 ]."
36934584
reach
"22 , 23 With the establishment of BV2 microglial cells under oxygen and glucose deprivation (OGD) and middle cerebral artery occlusion (MCAO) in mice as models of ischemia, the results from Xiang and his partners suggested that the ubiquitin‐specific protease 18 (USP18) reduced HI injury via the suppression of microglial activation by negatively inhibiting the JAK‐STAT pathway."
37786415
reach
"USP18 negatively regulates JAK–STAT signalling independently of its isopeptidase activity by binding to the IFNAR2 sub-unit of the type 1 interferon receptor and interfering with the JAK receptor interaction [18,19]."
37756534
reach
"Taken together, we concluded that USP18 potentiates the anti-HBV activity of IFN-alpha by targeting the JAK and STAT signaling pathway in Hepg2.2.15 cells."
27227879
reach
"As expected, exogenous USP18 expression significantly inhibited IFN-a-induced Jak and STAT signaling as shown by decreased p-STAT1 levels and ISRE activity."
29285303
reach
"Through IFNAR1/2 receptors and the JAK/STAT signaling pathway, IFN-I has a further impact on the next important component of the development of the inflammatory response: the ISG15/USP18 axis, which regulates the activity of the immune system [36] and reduces the inflammatory response intensity by inhibiting the JAK/STAT signaling pathway, indicating that there possibly exists a negative feedback loop between USP18, IFN-I, and, therefore, TNF-α [43, 44]."
39188267
reach
"Suppression of USP18 activated the JAK and STAT signaling pathway as shown by the increased and prolonged expression of phosphorylated signal transducer and activator of transcription 1 (p-STAT1) in combination with enhanced expression of several interferon stimulated genes (ISGs)."
27227879
reach
"Usp18 can inhibit JAK/STAT signaling, while Calb2 is an unreported regeneration response, suggesting that JAK-STAT signaling may mediate the expression of immune-related genes in SCs of the chicken basilar papilla following HC damage, thus leading to the regeneration of new HCs."
38015350
reach
"It has been reported that C-terminal region of USP18 (amino acid residue 312-368) competes with Jak1 for interacting with the type I IFN receptor (IFNAR2) and represses downstream Jak and STAT signaling pathway [XREF_BIBR]."
29285303
reach
"In humans, USP18 negatively regulates the JAK–STAT signaling pathway, and is therefore considered to be an inhibitor of type-I anti-viral signaling ( Malakhov et al., 2002, 2003 )."
25446846
reach
"Moreover, USP18 competitively inhibits IFN-alpha and beta-induced JAK and STAT activation [XREF_BIBR] and upregulates epidermal growth factor receptor (EGFR) expression [XREF_BIBR]."
26046984