IndraLab

Statements

STX1A binds KCNQ2 and KCNQ3. 3 / 3
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"In addition, we compared the binding of brain syntaxin 1A to KCNQ2 and KCNQ3 in a pull-down assay from synaptosomes ( xref )."
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"Following our previous studies, in which we characterized syntaxin 1A's interactions with Kv channels xref – xref , xref , xref , we studied the interaction of syntaxin 1A with KCNQ2, KCNQ2/3 and KCNQ3 channels in the heterologous expression system of Xenopus oocytes, where biochemical and electrophysiological analyses can be performed simultaneously."
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"Next, we assessed the functional consequences of syntaxin 1A binding to the KCNQ2, KCNQ2/3 and KCNQ3 channels by two-electrode voltage clamp analysis of currents evoked by depolarizing potentials in oocytes coexpressing the subunits with syntaxin 1A. However, whereas oocytes expressing KCNQ2 alone or together with KCNQ3 exhibited large outward non-inactivating potassium currents, oocytes expressing KCNQ3 alone did not exhibit any detectable current, in agreement with previous studies xref , xref – xref ."
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