IndraLab

Statements

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"Based on the above results, we found that depletion of USP5 significantly suppressed stemness properties, EMT, and metastasis in lung cancer."
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"Results elucidated that USP5 contribute to cell invasion and metastasis in pancreatic cancer."
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"Thus, USP5 may promote pancreatic cancer progression and metastasis through enhancing STAT3 signaling."
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"USP5 has been found to promote the epithelial-mesenchymal transition (EMT) and metastasis in NSCLC cells (35)."
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"These data indicated that USP5 promotes NSCLC metastasis by inducing EMT."
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"Finally, analyses of the TCGA‐LIHC database and 20 pairs of HCC tissues showed that USP5 and c‐Myc transcript levels were positively correlated with glycolytic gene expression levels (Supplementary Figure S11, Supplementary Figure S12).3.6 METTL5 promoted HCC growth and metastasis."
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"Additionally, USP5 activates the expression of downstream glycolysis-related genes (LDH-A, ENO1, TPI1, SLC2A1, and PKM2) by inhibiting K48-linked polyubiquitination of c-Myc, driving glucose metabolic reprogramming and metastasis in hepatocellular carcinoma [24]."
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"Specifically, overexpression of USP5 (a ubiquitin-specific protease) leads to the deubiquitination of the WT1 protein and increased WT1 expression, suppressing E-calmodulin expression and promoting cancer metastasis."
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"In summary, our work demonstrates that USP5 promotes β-catenin stabilization and Wnt signaling activation to control cancer stemness and metastasis in lung cancer."
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"These in vivo findings suggest that suppressing USP5 impedes both tumor growth and lung metastasis in CCA, highlighting the potential of USP5 as a therapeutic target for CCA.In the previous decade, a [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"By establishing USP5 overexpression in the MM.1S cell line and silencing USP5 in the NCI-H929, U266 and INA-6 cell lines, we demonstrated for the first time that USP5 effectively promoted MM cell proliferation and metastasis, glycolysis, and lactate formation, corroborating the findings of Peng et al. [23]."
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"USP5 enhanced epithelial-mesenchymal transition (EMT)-induced metastasis by stabilizing SLUG."
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"USP5 promotes OS metastasis by activating the Hedgehog (Hh) signaling pathway, as demonstrated in cultured cells and animal models."
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"USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt / beta-Catenin Pathway Ubiquitin-specific protease 5 ( USP5 ) is a deubiquitinating enzyme that functions as an oncoprotein in a variety of human cancers ."
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"USP5 promotes EMT and metastasis in hepatocellular carcinoma."
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"USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2alpha ."
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"Corrigendum : USP5 Promotes Metastasis in Non Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition"
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"All the results indicated that USP5 promotes the growth and metastasis of hepatocellular carcinoma."
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"USP5 overexpression promotes the progression and metastasis of pancreatic cancer."
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"USP5 Promotes Metastasis in Non Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt and beta-Catenin Pathway."
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"USP5 knockdown inhibits the progression and metastasis of pancreatic cancer."
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"Taken together, these results suggested that USP5 could evidently promote pancreatic cancer cells proliferation and metastasis."
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"The results clearly showed that knockdown of USP5 expression in CL1-5 cells had suppressed lung metastasis at day 21 postinjection (Fig. 3H)."
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