IndraLab

Statements

OPTN activates CYLD. 5 / 5
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"The main feature of this model is that optineurin mediates binding of CYLD to ubiquitinated RIP."
21408173
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"The results presented in this manuscript suggest that optineurin mediates interaction of deubiquitinase CYLD with polyubiquitinated RIP and this interaction is essential for deubiquitination of RIP by CYLD."
21408173
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"We further showed that Optn targets the deubiquitinase CYLD to TBK1 in order to downregulate the antiviral innate immune pathway."
25923723
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"We therefore concluded that Optn targets the deubiquitinase activity of CYLD to TBK1 to prevent its activity and to dampen the antiviral response."
25923723
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"Furthermore, optineurin inhibits the antiviral innate immune response by targetting CYLD to TBK1 to suppress its kinase activity, subsequently inhibiting interferon production."
29867991