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Probucol leads to the deubiquitination of KCNH2. 2 / 2
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"In summary, the present study provides evidence that probucol does not block the hERG channel, but accelerates degradation of the mature hERG channel and inhibit hERG current by decreasing SGK1 expression level and eventually enhancing the ubiquitination of the hERG channel through the E3 ubiquitin ligase Nedd4-2, whereas CCh can rescue probucol disrupted hERG surface expression by enhancing the phosphorylation level of Nedd4-2 as an alternative to SGK1."
26229434
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"Therefore we proposed the hypothesis that probucol treatment decreases hERG-channel expression by increasing Nedd4-2-mediated hERG ubiquitination."
26229434