IndraLab

Statements

USP6 activates Wnt. 8 / 8
| 8
reach
"In a separate whole-genome siRNA screen, USP6 was found to activate Wnt signalling by deubiquitylating Frizzled receptors and increasing their plasma membrane expression 28."
28064438
reach
"USP6 enhances Wnt signaling by deubiquitylating Fzds, thereby increasing their cell-surface abundance."
27162353
reach
"USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds."
27162353
reach
"A genomewide siRNA screen revealed that deubiquitinase USP6 overexpression could activate Wnt signaling by inhibition of Fzd7 endocytosis and its subsequent targeting for degradation [XREF_BIBR]."
28913633
reach
"USP6 promotes Wnt signaling by deubiquitylating Fzds, increasing their cell-surface presence."
40348771
reach
"Interestingly, the Wnt antagonist Dickkopf-1 (DKK1) or LRP5/6 siRNA blocked USP6 induced Wnt signalling, suggesting that a Wnt-ligand receptor complex is required for USP6 function."
34414184
reach
"For example, Madan et al. showed that the USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds and inhibition of Wnt signaling significantly decreased the growth of USP6-driven xenograft tumors [20]."
36474192
reach
"Additionally, the deubiquitinating enzymes UBPY and USP6 may promote the recycling of endocytosed FZD back to the surface and restore Wnt signaling."
29632210