IndraLab

Statements

USP6 activates Wnt. 6 / 6
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"Additionally, the deubiquitinating enzymes UBPY and USP6 may promote the recycling of endocytosed FZD back to the surface and restore Wnt signaling."
29632210
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"Interestingly, the Wnt antagonist Dickkopf-1 (DKK1) or LRP5/6 siRNA blocked USP6 induced Wnt signalling, suggesting that a Wnt-ligand receptor complex is required for USP6 function."
34414184
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"A genomewide siRNA screen revealed that deubiquitinase USP6 overexpression could activate Wnt signaling by inhibition of Fzd7 endocytosis and its subsequent targeting for degradation [XREF_BIBR]."
28913633
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"USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds."
27162353
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"USP6 enhances Wnt signaling by deubiquitylating Fzds, thereby increasing their cell-surface abundance."
27162353
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"In a separate whole-genome siRNA screen, USP6 was found to activate Wnt signalling by deubiquitylating Frizzled receptors and increasing their plasma membrane expression 28."
28064438