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FGF12 binds SCN5A. 4 / 6
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"For the interaction between FGF12 and SCN5A, we predicted rewiring due to mutations in FGF12, in which the deleterious variant is more frequent in East Asians than in Americans (Figure 5b, thick and thin edges, respectively)."
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"We showed that a loss-of-function mutation in FGF12 that eliminates Na + channel modulation is associated with Brugada syndrome, an inherited cardiac arrhythmia[ xref ], and a mutation in the cardiac Na + channel gene SCN5A that affects FGF12 interaction and Na V 1.5 channel function in ventricular myocytes leads to a life-threatening arrhythmia syndrome[ xref ]."
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"For the interaction between FGF12 and SCN5A, we predicted rewiring due to mutations in FGF12, in which the deleterious variant is more frequent in East Asians than in Americans ( xref b, thick and thin edges, respectively)."
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"More specifically, experiments revealed the reduced binding of the mutant FGF12 to SCN5A and the resulting reduction in sodium channel current, which affected the cardiac ventricular action potential."
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