IndraLab

Statements

OTUB1 inhibits Interferon. 3 / 3
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"On the other hand, OTUB1 has a seemingly paradoxical function in which it promotes IAV replication, as overexpression of OTUB1 was previously reported to repress virus-triggered interferon induction and other host antiviral responses [33]."
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"These findings suggest that OTUB1 and OTUB2 negatively regulate virus triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 and -6."
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"As a result, OTUB1 deletion causes defects in NF-κB and IRFs (interferon regulatory factor) responses after RNA virus infection."
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