IndraLab

Statements

reach
"Further experiments indicated that such degradation of IkappaBalpha accelerated by IFIT5 was inhibited by MG132, a proteasome inhibitor, whereas IKKbeta phosphorylation enhanced by IFIT5 remained unaf[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26334375
reach
"In in vitro studies using protease inhibitors, IkappaBalpha proteolysis in ts1 infected astrocytes was significantly blocked by a specific calpain inhibitor calpeptin but not by MG-132, a specific proteasome inhibitor, whereas rapid IkappaBbeta proteolysis was blocked by MG-132."
11582519
reach
"To assess whether TSPAN15 promotes the BTRC mediated degradation of p-IkappaBalpha, TSPAN15 expressing cells and control cells were further treated with a proteasome inhibitor MG132 (Selleck Chemicals, Houston, TX)."
29650964
reach
"In addition, inhibition of IkappaB-alpha degradation by MG-132 resulted in apoptosis."
15528993
reach
"We used an NFkappaB dependent luciferase reporter assay to confirm that MG132 suppressed NFkappaB activity by inhibiting the proteasomal degradation of IkappaBalpha."
21843349
reach
"Three hours later, IkappaBalpha starts to degrade, and ERK returns to basal or non phosphorylation, and this lasts for the next 12 h. Finally, expression of CD3 and CD8 occurs in MOLT-4 along with reappearance of the IkappaBalpha.ERK.WWOX complex near 24 h. Inhibition of ERK phosphorylation by U0126 or IkappaBalpha degradation by MG132 prevents MOLT-4 maturation."
27339895
reach
"A proteasome inhibitor, MG132, was used to inhibit degradation of IkappaBalpha in cells cotransfected with CIS and V5-IkappaBalpha vectors as previously reported."
19592657
reach
"In order to check that the decreased band intensity in IKKbeta expressing cells was due to accelerated degradation of IkappaBalpha, one set of cells were also treated with the proteasome inhibitor MG-132 for 2hours, resulting in equal IkappaBalpha protein levels in both the samples."
22590978
reach
"In a manner consistent with this observation, ZnO stimulation in the absence of MG132 caused IkappaBalpha degradation at 30 min exposure to ZnO (XREF_FIG)."
20194077
reach
"In summary, we showed that the proteasome inhibitor MG132 is able to inhibit the activation the NFkappaB pathway by inhibiting the degradation of IkappaBalpha in vitro."
21843349
reach
"PD98059 as well as MG132, an NF-kappaB pathway inhibitor, blocked both IL-8 production and degradation of IkappaBalpha induced by H. pylori infection, whereas only PD98059 inhibited ERK activity in response to H. pylori."
12106602
reach
"Both MG115 and MG132 markedly inhibited the I of IKBa observed in response to TNFa."
7538441
reach
"IkappaBalpha proteolysis induced by TNF-alpha occurred through the 26S proteasome, as both 26S proteasome activity and IkappaBalpha proteolysis were blocked by specific inhibitors lactacystin, MG-132, and ZLLF-CHO."
9573251