IndraLab

Statements

USP2 is ubiquitinated. 3 / 3
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"In addition, cancer-associated SPOP mutants showed reduced activity for promoting USP2 ubiquitination in cells ( xref )."
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"We further confirmed that SPOP could promote the ubiquitination of wild-type USP2, but not the degron 2 mutant form of USP2 ( xref )."
41534899
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"Although we have identified USP2 as a pivotal DUB enzyme that deubiquitinates and stabilizes the CD47 protein, the physiological ubiquitin E3 ligase responsible for promoting USP2 ubiquitination and subsequent degradation remains largely unknown."
41534899