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USP2 increases the amount of PPARG. 7 / 7
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"In this study, USP2 deficiency reduced PPAR-γ expression and increased its protein ubiquitination (Fig. 4)."
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"WT USP2 overexpression induced an increase in the protein level of PPAR-γ and decreased PPAR-γ ubiquitination, but not USP2 C276A (an enzyme-activity dead mutation) overexpression (Fig. 4C)."
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"Usp2 overexpression increased PPAR-γ protein levels in the Gas muscles of diabetic mice (Fig. 5C)."
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"Knockdown of PPAR-γ reduced and Usp2 overexpression increased the levels of PPAR-γ, IRS1, and GLUT4 in C2C12 cells (Fig. 6A)."
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"USP2 Upregulates PPAR-gamma Expression and Improves Insulin Signaling."
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"Usp2 knockdown reduced the expression of PPAR-γ, GLUT4, and IRS1, and increased atrogene expression under DEX stimulation (Supplementary Fig. 4A)."
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"In contrast, Usp2 overexpression induced the expression of PPAR-γ, GLUT4, and IRS1, and reduced the expression of atrogenes under DEX stimulation (Supplementary Fig. 4B)."
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