IndraLab

Statements

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"GYY4137 reduced the DSM relaxation induced by the BK channel opener, NS11021."
25948731
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"have found that the reduction of BK channel activity in detrusor smooth muscle (DSM) is caused by PKC activation via a Ca 2+ -dependent mechanism, thus enhancing DSM contractility."
28955251
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"To further investigate the mechanism of BK channel activation in decreasing DSM contractility, rat DSM strips were pre-contracted under conditions of moderately (20 mM K +) or highly elevated extracellular K + (60 mM K +)."
21914438
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"BK channel inhibition with iberiotoxin increases DSM excitability, 14 and analogous increases in DSM excitability are caused by experimental PUO."
22158596
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"BK channel blockers have been shown to increase DSM contractility and excitability."
21914438
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"In contrast, BK channel openers lead to hyperpolarization of cell membranes and have been identified as promising candidates to decrease DSM cell excitability and relax smooth muscle."
21914438
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"Here, we hypothesized that pharmacological opening of the BK channel with NS1619 can reduce DSM contractility under various experimental conditions."
21914438
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"3.2 BK channel activation with NS1619 reduces pharmacologically induced DSM contractions."
21914438
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"Thus during smooth muscle excitation when membrane potential depolarizes and intracellular Ca 2+ levels increase, BK channel opening is thought to promote a reduction in DSM excitability and subsequent attenuation of contractility."
23344746
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"Consistent with the patch-clamp and molecular data, the results of our functional studies established that reduced BK channel activity increases DSM contractility in HFD rats.The complicated etiology of OAB is not completely understood [1]."
31480021
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"3.3 BK channel activation with NS1619 reduces the nerve evoked contractions in DSM isolated strips."
21914438