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HIF1A binds USP13. 7 / 7
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"Luciferase assays revealed that HIF-1α specifically binds to Region #2 of the USP13 promoter (Fig. xref )."
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"USP13 directly bound HIF-1α via its C-terminal UBA domain, cleaving K48-linked polyubiquitin chains to stabilize HIF-1α and enhance its transcriptional activity."
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"USP13-HIF-1α interaction was assessed via co-immunoprecipitation (co-IP), immunofluorescence, and domain mapping."
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"In this study, we found that the HIF-1α K532R mutation significantly reduced the interaction between HIF-1α and USP13 (Fig.  xref B)."
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"USP13 interacts with HIF-1α."
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"Subsequently, we carried out co-IP experiments to verify the interaction between HIF-1α and USP13."
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"The interaction between USP13 and HIF-1α was also validated in tumor tissues formed by MC38 cells and in CRC model (Fig. S5)."
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