IndraLab

Statements

Curcumin inhibits NFKB1. 31 / 31
5 | 26
ctd
No evidence text available
19225048
reach
"XREF_BIBR, XREF_BIBR Curcumin inhibits NFKB activity in different cell types (XREF_TABLE) and the inhibition of the NFKB pathway can be seen by decreased expression of NFKB."
24665206
reach
"Down-regulation of NFkB by Curcumin and accompanied apoptosis induction was observed in various tumor models and discussed as main mechanism of Curcumin’s impact on tumor biology ."
32123256
reach
"In pancreatic cancer cell lines radiation-induced NFkB activity was inhibited by Curcumin consequential leading to a significantly higher apoptosis induction ."
32123256
reach
"Curcumin downregulates NF-KB and STAT 3 and MCP- 1 consequentially and protects both retinal neurons and microvasculature as per Wang et al. [67]."
35015114
reach
"XREF_BIBR - XREF_BIBR Curcumin could also decrease the expression of MAPKs down-stream of NFKB1 in order to inhibit paclitaxel induced upregulation of survival signaling events in HeLa cells."
26273408
reach
"Subsequently, curcumin inhibits the activation of NF-KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs, and iNOS."
17569214
reach
"Curcumin treatment blocked activation of p50 and p65, which was significantly activated by pretreatment with 1 muM PGE 2 for 2 h (XREF_FIG)."
25431425
reach
"Curcumin can inhibit NFKB activity indirectly by stabilization of NFKBIA."
24665206
reach
"NFkB reporter assay and western blot analysis of nuclear as well as cytosolic fractions of NFkB revealed that curcumin inhibits NFkB activation whereas inhibition was much less with dimc."
29621898
reach
"Curcumin causes inhibition of NF-KB whose activation induces the apoptotic degenerative process and downregulation of cellular inflammatory genes."
35015114
reach
"Our results indicate that p50 activity is increased during MV and that both SN50 and curcumin treatment attenuates the increase in p50 activation (XREF_FIG)."
22080641
reach
"Additionaly, curcumin significantly decreased p-p38 MAPK positive cells and NFkB immunoreactivity, while significantly increasing Nrf2 immunoreactivity in the kidney tissue."
35489078
ctd
No evidence text available
16173963
reach
"Interestingly, NFkB downstream effectors such as COX-2, PGE2and IL-8 were also down-regulated by curcumin treatment."
23111102
reach
"Indeed, curcumin has also been shown to inhibit mediators of inflammation such as cyclo-oxygenase-2 and lipooxygenase (two enzymes involved in inflammation), inducible nitric oxide synthase (enzyme that catalyzes the production of nitric oxide), cytokines and NFKB."
27610163
reach
"Curcumin has been shown to inhibit induction of AP-1 and NFkB in bone marrow stromal cells [XREF_BIBR]."
17979888
reach
"We conclude that curcumin may attenuate gentamicininduced nephrotoxicity by supprresing the p38 MAPK and NFkB, and activating the Nrf2 signaling pathways."
35489078
ctd
No evidence text available
16023083
reach
"Curcumin treatment has been shown to reduce NF-kb activation during inflammatory events."
28948066
reach
"As shown in XREF_FIG, curcumin treatment for 24 h time-dependently reduced the activation of different NF-kappaB subunits (p50 and p65)."
25431425
ctd
No evidence text available
17596214
reach
"Curcumin, an active anti-inflammatory compound in Indian spices, can inhibit NFkB complex activation and IL-8 induction in gastric cells infected with H. pylori [XREF_BIBR, XREF_BIBR]."
20585917
reach
"Furthermore, increasing evidence indicates that curcumin inhibits NFkB activation, efficiently preventing cell death [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23618527
reach
"The supershift assay showed that TNFalpha increases neuroblastoma NF-kappaB activity through the canonical pathway, specifically through increases in the p50 and p65 subunits; curcumin blocked the p50 and p65 subunit activation as seen by antibody shift (XREF_FIG)."
22284765
reach
"Moreover, curcumin suppresses nuclear localization of p50 and all VIP effects mediated by p50 (COX-2 and PGE 2 and VEGF)."
25446255
reach
"Among its many activities, which are mainly anti-inflammatory and anticancer, curcumin inhibits cytochrome P450s, down-regulates NFkB, and affects apoptosis and the cell cycle."
21279680
reach
"However, pretreatment with PGE 2 attenuated curcumin induced inhibition of p50, p65, and RelB of NF-kappaB signaling (XREF_FIG)."
25431425
reach
"Curcumin has been shown to down-regulate the NFkB signaling pathway thereby inducing apoptosis, which has been found be an important mechanism of AKI."
29311922
ctd
No evidence text available
17041101
reach
"Besides TNF inhibition, curcumin is also able to block phorbol ester and hydrogen perox- ide mediated activation of NF-KB (Singh and Aggarwal, 1995)."
9561563