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Curcumin inhibits NFKB1. 41 / 51
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"Curcumin has been shown to down-regulate the NFkB signaling pathway thereby inducing apoptosis, which has been found be an important mechanism of AKI."
29311922
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"Among its many activities, which are mainly anti-inflammatory and anticancer, curcumin inhibits cytochrome P450s, down-regulates NFkB, and affects apoptosis and the cell cycle."
21279680
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"This hypothesis is confirmed by the evidence that curcumin decreased proinflammatory cytokines and transcription factors (tumor necrosis factor, IL-6, NFkB, and VEGF) in multiple myeloma patients, as well as the tumor markers carcinoembryonic antigen and prostate-specific antigen in breast and prostate cancer patients, respectively [29,31,33]."
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"Curcumin blocks the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-KB), the Cox-2 expression mediator, and the AP1 transcription factor by blocking the activity o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32585392
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"The supershift assay showed that TNFalpha increases neuroblastoma NF-kappaB activity through the canonical pathway, specifically through increases in the p50 and p65 subunits; curcumin blocked the p50 and p65 subunit activation as seen by antibody shift (XREF_FIG)."
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"Curcumin reduces Nf-kB, and beetroot, garlic, and berry fruits have antioxidant and anti-inflammatory effects [139].-Vegetable foods, compared to animal foods, have a lower content of advanced glycation end products (AGEs), even when comparable cooking methods are used [140]."
37834781
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"NFkB reporter assay and western blot analysis of nuclear as well as cytosolic fractions of NFkB revealed that curcumin inhibits NFkB activation whereas inhibition was much less with dimc."
29621898
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"Curcumin has been shown to inhibit induction of AP-1 and NFkB in bone marrow stromal cells [XREF_BIBR]."
17979888
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"As shown in XREF_FIG, curcumin treatment for 24 h time-dependently reduced the activation of different NF-kappaB subunits (p50 and p65)."
25431425
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"However, pretreatment with PGE 2 attenuated curcumin induced inhibition of p50, p65, and RelB of NF-kappaB signaling (XREF_FIG)."
25431425
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"Curcumin treatment has been shown to reduce NF-kb activation during inflammatory events."
28948066
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"Down-regulation of NFkB by Curcumin and accompanied apoptosis induction was observed in various tumor models and discussed as main mechanism of Curcumin’s impact on tumor biology ."
32123256
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"In pancreatic cancer cell lines radiation-induced NFkB activity was inhibited by Curcumin consequential leading to a significantly higher apoptosis induction ."
32123256
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"Curcumin treatment blocked activation of p50 and p65, which was significantly activated by pretreatment with 1 muM PGE 2 for 2 h (XREF_FIG)."
25431425
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"XREF_BIBR, XREF_BIBR Curcumin inhibits NFKB activity in different cell types (XREF_TABLE) and the inhibition of the NFKB pathway can be seen by decreased expression of NFKB."
24665206
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"Our results indicate that p50 activity is increased during MV and that both SN50 and curcumin treatment attenuates the increase in p50 activation (XREF_FIG)."
22080641
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"Moreover, curcumin suppresses nuclear localization of p50 and all VIP effects mediated by p50 (COX-2 and PGE 2 and VEGF)."
25446255
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"Furthermore, in a human neuroblastoma cell line it has recently been shown that curcumin inhibits NFkB activation, effectively preventing neuronal cell death, [159] ."
15896810
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"Moreover, curcumin downregulates NFkB regulated gene products involved in apoptosis, matrix degradation, and inflammation in human tenocytes in vitro (16)."
26540017
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"Curcumin can inhibit NFKB activity indirectly by stabilization of NFKBIA."
24665206
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"This observation is consistent with previously reported findings that curcumin reduces WAT inflammation, stimulated by HFD in B6 mice, via the Tlr-4/NfkB pathway in adipose tissue [3,37]."
38201900
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"XREF_BIBR - XREF_BIBR Curcumin could also decrease the expression of MAPKs down-stream of NFKB1 in order to inhibit paclitaxel induced upregulation of survival signaling events in HeLa cells."
26273408
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"Subsequently, curcumin inhibits the activation of NF-KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs, and iNOS."
17569214
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"Curcumin is known to inhibit both mTOR and NFkB in human cells ( Sun et al., 2011 )."
23063786
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"Treatment with curcumin inhibited the activation of NF-κB p50 and completely blocked the activation of NF-κB p65."
17996675
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"Curcumin blocks the NFkB and hemeoxygenase-1 pathways, which are responsible for the structural moieties of the α, β-unsaturated diketone that serves as an acceptor in the Michael reaction."
36144994
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"Curcumin can inhibit NF-kb, limiting IL-6 production [5,13]."
35453772
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"Further, it was observed that the addition of both DPCPX and curcumin also reduces NFkB activation and this reduction with curcumin was even greater than dexamethasone alone."
32758568
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"Curcumin, an active anti-inflammatory compound in Indian spices, can inhibit NFkB complex activation and IL-8 induction in gastric cells infected with H. pylori [XREF_BIBR, XREF_BIBR]."
20585917
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"Relatively lower phospho p65NFkB expression after treatment with trans -resveratrol in the presence of curcumin and dexamethasone compared to either dexamethasone alone or dexamethasone with DPCPX cou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32758568
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"Curcumin has previously been shown to inhibit NFkB activation by preventing IkB degradation due to inhibition of IKK ( Marquardt et al., 2015 ; Gonzales and Orlando, 2008 )."
32758568
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"Curcumin treatment prevented the activation of NF-KB pathway indirectly by inhibiting the degradation of IκBα."
26713546
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"Indeed, curcumin has also been shown to inhibit mediators of inflammation such as cyclo-oxygenase-2 and lipooxygenase (two enzymes involved in inflammation), inducible nitric oxide synthase (enzyme that catalyzes the production of nitric oxide), cytokines and NFKB."
27610163
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"In this way, curcumin blocks NF-kb activation induced by various agent such as TNFα and H 2 O 2 [46] ."
24583398
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"Curcumin treatment prevented the activation of NF-KB pathway indirectly by inhibiting the degradation of IκBα, which in turn suppressed the production of pro-inflammatory cytokines TNFα and CRP.Fructo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26713546
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"Furthermore, increasing evidence indicates that curcumin inhibits NFkB activation, efficiently preventing cell death [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23618527
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"Interestingly, NFkB downstream effectors such as COX-2, PGE2and IL-8 were also down-regulated by curcumin treatment."
23111102
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"Curcumin prevents muscle damage by regulating NFkB and Nrf2 pathways and improves performance : an in vivo model."
29493344
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"Besides TNF inhibition, curcumin is also able to block phorbol ester and hydrogen perox- ide mediated activation of NF-KB (Singh and Aggarwal, 1995)."
9561563
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"Additionaly, curcumin significantly decreased p-p38 MAPK positive cells and NFkB immunoreactivity, while significantly increasing Nrf2 immunoreactivity in the kidney tissue."
35489078
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"We conclude that curcumin may attenuate gentamicininduced nephrotoxicity by supprresing the p38 MAPK and NFkB, and activating the Nrf2 signaling pathways."
35489078