IndraLab

Statements

HSP104 inhibits ATXN3. 3 / 3
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"Importantly, in staging experiments, Hsp104 suppressed toxicity of a C-terminal MJD fragment when expressed after the onset of PolyQ induced degeneration, whereas Hsp70 was ineffective."
24039611
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"XREF_BIBR Notably, Hsp104 suppressed toxicity of a C-terminal ataxin-3 fragment when expressed even after the onset of polyglutamine induced degeneration."
24401655
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"Hsp104 suppressed toxicity of MJD variants lacking a portion of the N-terminal deubiquitylase domain and full-length MJD variants unable to engage polyubiquitin, indicating that MJD-ubiquitin interactions hinder protective Hsp104 modalities."
24039611