IndraLab

Statements

USP13 binds SIGIRR. 6 / 6
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"To determine molecular mechanisms by which GSK3β promotes Sigirr degradation, we examined the effect of GSK3β-mediated phosphorylation on the association between Sigirr and USP13."
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"Overexpression of GSK3β reduced the association between Sigirr and USP13 (Fig. 7B), suggesting that GSK3β-mediated phosphorylation prevents Sigirr degradation from Sigirr interaction with its stabilizer, USP13."
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"USP13 is associated with Sigirr."
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sparser
"Co-immunoprecipitation (Co-IP) also revealed USP13's association with Sigirr ( xref b, c)."
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"Indeed, the T372 site is within the USP13 binding site, thus GSK3β-mediated phosphorylation of this residue modifies the conformation preventing IL-1R8/USP13 interaction and IL-1R8 stabilization ( Fig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overexpression of GSK3β reduced the association between Sigirr and USP13 ( xref ), suggesting that GSK3β-mediated phosphorylation prevents Sigirr degradation from Sigirr interaction with its stabilizer, USP13."
33400290