IndraLab

Statements


TNF increases the amount of IL6ST. 11 / 11
| 11

reach
"Enhancement of IL-6 receptor beta chain (gp130) expression by IL-6, IL-1 and TNF in human epithelial cells."

reach
"Exceptions existed, where TNF stimulation failed to induce the release of gp130/sIL-6Rb, sTNF-R2 and osteopontin in PBMCs from patients with rhupus, and gp130/sIL-6Rb, IL-26, sTNF-R2 and osteopontin in patients with SLE."

reach
"The expression of IL-6R was significantly increased by TNF (1000 ng/ml) during a 4 hr-incubation period, and its expression remained at nearly the maximal level until 6 hr after the stimulation (Fig. [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"The increase in IL-6R expression by TNF would be adequate to evoke a substantial neuroprotective effect of IL-6 in PC12 cells.It has been reported that, when neurones are damaged, microglia migrate to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Meanwhile, figure 2 illustrates that TNF-stimulated PBMCs displayed similar levels of gp130/sIL-6Rb and APRIL across the study groups, despite their elevated levels in patients with rhupus compared with controls.The connection between inflammatory molecule production and lupus activity was examined."

reach
"On the other hand, both TNF-alpha and LPS upregulate gp130 surface expression and its release from vascular endothelial cells."

reach
"TNF-α increases expression of the gp130 protein component of the IL-6 receptor signalling system and this may account for the synergy that occurs between IL-6 and TNF-α in their ability to stimulate e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"In RASF, the expression of gp130 subunit was significantly up-regulated by TNF-α stimulation [ 37 ]."

reach
"Moreover, we found that TNF-alpha and IL-6 secreted by activated Kupffer cells dramatically increased TNFR1 and GP130 expression in hepatocytes compared to untreated control cells."

reach
"Gp130 expression is induced by TNF-α, IL-10, IL-27, and IL-35 ( Ye et al., 2021; Yu et al., 2007; Traum et al., 2012; Guzzo et al., 2012 )."

reach
"In RASFs, the expression of gp130 subunit was significantly upregulated by TNFalpha while the IL12Rbeta2 receptor subunit was expressed neither constitutively nor induced by TNFalpha."