IndraLab

Statements

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"In addition, the enhanced USP17L2–SIRT7 axis modulates DNA damage response and chemo-response in breast cancer, highlighting a potential therapeutic vulnerability [26]."
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"Overexpression of Dub3 induces cell cycle arrest at S and G2 phases and activates the DNA damage response via stabilization of Cdc25A protein."
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"In contrast, acute Dub3 overexpression produced a signature response to oncogene induction : cells accumulated in S and G2 because of replication stress, and activated a DNA damage response."
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