IndraLab

Statements

STAT3 binds USP28. 19 / 23
4 | 7 12
sparser
"USP28 interacted with STAT3, and increased the stability of STAT3 by inducing its deubiquitination."
30881015
reach
"We also found that USP28 interacted with STAT3, and stabilized STAT3 by decreasing its polyubiquitination, which indicated that STAT3 was a potential substrate of USP28 (XREF_FIG and XREF_FIG)."
30881015
sparser
"This interaction between STAT3 and USP28 was further confirmed by IP with anti-USP28 antibody and then blotting with anti-STAT3 antibody, wherein STAT3 protein was also found in the USP28 immunoprecip[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36442624
sparser
"The fact that USP28 interacted with STAT3, and both proteins were upregulated in ADPKD kidneys prompted us to speculate that USP28 may regulate STAT3 as a deubiquitinase."
36442624
sparser
"The deubiquitinating enzyme USP28 mediates STAT3 signaling in non-small-cell lung cancer cells, and USP28 interacts with STAT3 and enhances its stability by inducing the deubiquitination of STAT3 [ xref ]."
39773987
sparser
"A previous study demonstrated that the deubiquitinating enzyme USP28 directly interacts with STAT3 and increases its stability. xref Thus, regulation of STAT3 acetylation and recruitment of E3 ligase or deubiquitinating enzymes might be associated with the regulation of STAT3 protein stability by SA14."
35858011
sparser
"Immunoprecipitation was performed to assess whether USP28 interacted with STAT3 or deubiquitinated STAT3."
30881015
sparser
"USP28 interacted with STAT3 and decreased the polyubiquitination of STAT3, thereby increasing the stability of STAT3."
30881015
sparser
"USP28 interacts with STAT3 and decreases its polyubiquitination level."
30881015
sparser
"To evaluate whether USP28 interacted with STAT3, the reciprocal Co-IP was performed."
30881015
sparser
"As shown in xref , the Co-IP revealed that exogenous USP28 interacted with exogenous STAT3 protein."
30881015
sparser
"Additionally, the Co-IP in xref showed that endogenous STAT3 also interacted with endogenous USP28."
30881015
sparser
"We also found that USP28 interacted with STAT3, and stabilized STAT3 by decreasing its polyubiquitination, which indicated that STAT3 was a potential substrate of USP28 ( xref and xref )."
30881015
reach
"Immunoprecipitation was performed to assess whether USP28 interacted with STAT3 or deubiquitinated STAT3."
30881015
reach
"USP28 interacted with STAT3, and increased the stability of STAT3 by inducing its deubiquitination."
30881015
reach
"USP28 interacted with STAT3 and decreased the polyubiquitination of STAT3, thereby increasing the stability of STAT3."
30881015
reach
"USP28 interacts with STAT3 and decreases its polyubiquitination level."
30881015
reach
"To evaluate whether USP28 interacted with STAT3, the reciprocal Co-IP was performed."
30881015
reach
"Additionally, the Co-IP in XREF_FIG showed that endogenous STAT3 also interacted with endogenous USP28."
30881015