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USP22 deubiquitinates E2F6. 2 / 2
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"Furthermore, a recent study revealed that E2F6 can be deubiquitinated and stabilized by USP22 and thereby inhibit the transcription of DUSP1, which in turn activates AKT signalling and leads to HCC progression 47."
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"Deubiquitination of the repressor <span class="match term1">E2F6</span> by <span class="match term0">USP22</span> facilitates AKT activation and tumor growth in hepatocellular carcinoma"
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