IndraLab

Statements

METTL3 decreases the amount of USP4. 5 / 5
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"The present study demonstrates that metformin can repress the expression of THRAP3, RBM25, and USP4 by inhibiting METTL3-mediated m6A modification, which in turn hamper cell proliferation and promotes cell apoptosis."
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"Moreover, USP4 promoter transcriptional activity was not affected upon METTL3 knockdown, excluding the possibility that METTL3 downregulation inhibited USP4 transcription."
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"And thus, we chose USP4, USP8, USP11, USP25 and USP28 for further analyses, and western blotting revealled that METTL3 knockdown markedly increased USP4 protein levels."
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"Given the key role of m 6 A mRNA methylation in affecting mRNA stability, it was reasonable to speculate that METTL3 knockdown reduces the m 6 A modification levels in USP4 mRNA and thus increase USP4 mRNA levels by atenuating the inhibitory effect of m 6 A modification on USP4 mRNA stability."
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"We next found that METTL3 knockdown significantly upregulated USP4 mRNA levels in PCa cells."
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