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USP10 deubiquitinates IKBKG. 10 / 11
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"It showed that USP10 silencing caused an increased level of linear ubiquitination of NEMO ( Figure 3B )."
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"Most importantly, we found that USP10 silencing caused an increased level of linear ubiquitination of NEMO."
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"Thus, by mediating USP10 dependent deubiquitination of NEMO, MCPIP1 induction serves as a negative feedback mechanism for attenuating genotoxic NF-kappaB activation."
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"One example is USP10 that requires the protein MCPIP-1 (monocyte chemotactic protein induced protein 1) to interact with and deubiquitinate its substrate NEMO inhibiting the NF-kappaB signalling cascade [XREF_BIBR]."
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"MCPIP1 reportedly contributes to the inhibition of genotoxic NF-κB activation by regulating the USP10-dependent deubiquitination of NEMO [9] ."
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"By mediating USP10 dependent deubiquitination of NEMO, MCPIP1 serves in a negative feedback mechanism for attenuation of NF-kappaB activation [XREF_BIBR]."
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"USP10 deubiquitinates IKKgamma and NEMO, thereby inhibiting IKKgamma mediated nuclear factor kappaB (NF-kappaB) activation after genotoxic stress."
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"USP10 targets and deubiquitinates TRAF6 and NEMO to inhibit NF-κB and type I IFNs ( Wang et al., 2015b ; Niu et al., 2013 )."
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"MCPIP1 induction serves as a negative feedback mechanism for attenuating NF-kappaB activation in genotoxic response by mediating USP10 dependent deubiquitination of NEMO [13]."
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"The USP10-dependent deubiquitination of NEMO and TRAF6 proteins is another strategy through which MCPIP1 can regulate inflammation and the immune response [34]."
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