IndraLab

Statements

USP15 activates TAFAZZIN. 5 / 5
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"USP15 deficiency inhibited cell proliferation, migration, and YAP1/TAZ signaling in hypoxia-induced hPASMCs."
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"USP15 overexpression promoted hPASMC proliferation and migration in a YAP1/TAZ-dependent manner."
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"To further explore whether USP15 mediated hPASMC proliferation and migration in a YAP1/TAZ-dependent manner, we achieved the depletion of YAP1 or TAZ in USP15-overexpressing hPASMCs by corresponding adenovirus infection."
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"Human pulmonary artery smooth muscle cells (hPASMCs) were exposed to hypoxia to mimic PH in vitro, and USP15 knockdown significantly inhibited cell proliferation, migration, and YAP1/TAZ signaling in hypoxic hPASMCs."
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"Rescue assays further suggested that USP15 promoted hPASMC proliferation and migration in a YAP1/TAZ-dependent manner."
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