IndraLab

Statements

USP11 activates TP53. 6 / 8
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"A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage."
34141823
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"Further, rescue experiments were conducted invivo to validate the function of the USP11/p53/KLF2/NF-kappaB axis in ICH induced inflammation, which confirmed that USP11 silencing blocked the release of pro inflammatory cytokines following ICH by downregulating p53, thus protecting against neurological impairment."
34141823
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"Also, the combination of USP11 knockdown and restoration of p53 or KLF2 knockdown elevated the mNSS value (Figure 5B) and brain water content (Figure 5C) reduced by USP11 knockdown alone in rats with ICH-like symptoms."
34141823
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"Post DNA damage, USP11 activates p53 and its target genes such as Puma, Bax , and p21 [ xref ]."
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eidos
"Inhibition of USP11 expression reduces p53 levels and IKKalpha expression , as well as increasing the response of the NF-kappaB pathway to TNFalpha ( 197 ) ."
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"USP11 stabilizes and activates p53 following DNA damage by targeting ubiquitinated p53."
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