IndraLab

Statements

USP11 activates TP53. 6 / 8
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"A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage."
34141823
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"Also, the combination of USP11 knockdown and restoration of p53 or KLF2 knockdown elevated the mNSS value (Figure 5B) and brain water content (Figure 5C) reduced by USP11 knockdown alone in rats with ICH-like symptoms."
34141823
sparser
"USP11 stabilizes and activates p53 following DNA damage by targeting ubiquitinated p53."
32549302
sparser
"Post DNA damage, USP11 activates p53 and its target genes such as Puma, Bax , and p21 [ xref ]."
32549302
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"The reduction in USP11 levels significantly attenuates the induction effect of p53 on the DNA damage stress response ( Fig. 4 ) [ 36 ]."
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eidos
"Inhibition of USP11 expression reduces p53 levels and IKKalpha expression , as well as increasing the response of the NF-kappaB pathway to TNFalpha ( 197 ) ."
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