IndraLab

Statements

USP11 activates TP53. 3 / 5
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eidos
"Inhibition of USP11 expression reduces p53 levels and IKKalpha expression , as well as increasing the response of the NF-kappaB pathway to TNFalpha ( 197 ) ."
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reach
"A pro inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage."
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reach
"Further, rescue experiments were conducted invivo to validate the function of the USP11/p53/KLF2/NF-kappaB axis in ICH induced inflammation, which confirmed that USP11 silencing blocked the release of pro inflammatory cytokines following ICH by downregulating p53, thus protecting against neurological impairment."
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