IndraLab

Statements

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"USP22 promotes lipogenesis in Tregs through stabilization of peroxisome proliferator-activated receptor gamma (PPARγ) [51] ."
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"In support of this, gain-of-function or loss-of-function studies revealed that USP22 stimulates lipogenesis from glucose in cultured hepatocytes and subsequently contributes to tumorigenesis [193]."
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"Genetic and pharmacological inhibition of PPARγ abolished the regulatory effect on ACC and ACLY transcription, and significantly decreased lipogenesis and tumorigenesis caused by USP22 expression both in HCC cells and xenograft tissues."
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