IndraLab

Statements

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"XREF_BIBR, who demonstrated that Ni 2+ ions inhibited LPS induced p65 binding to DNA in a human monocyte cell line."
23844176
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"Chromatin immunoprecipitation revealed that LPS challenge decreased p65, increased p50 and p52, and had no effect on RelB and c-Rel binding to kappaB elements of the AQP2 promoter."
18703515
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"LPS up-regulated p65 was dramatically inhibited at 3 h, but was enhanced at 6 h by SFN pre-incubation in porcine moDCs (XREF_FIG)."
25793534
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"Results showed that both p65 nuclear translocation and NF-jB activity were promoted by lincRNA-p21 overexpression, while lincRNA-p21 inhibition showed a negative effect on LPS induced p65 nuclear translocation and increase of NF-jB activity."
32362153
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"Furthermore, Figure 8 also shows that the degradation of IκB and phosphorylation levels of p65 induced by LPS were inhibited by TFE in a dose-dependent manner."
29725269
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"Treatment using FaOH from the roots of Heracleum moellendorffii (H. moellendorffii) inhibited LPS-induced NF-κB signalling activation by inhibiting IκB-α degradation and nuclear accumulation of p65 [65] in RAW264.7 cells."
36981118
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"Interestingly, fenofibrate resulted in a strong interaction between SHP and the NF-kappaB subunit p65, which was reduced by LPS stimulation (XREF_FIG)."
23704907
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"Deletion of SOCS3 had no effect on LPS induced NF-kappaB p65 and ERK1/2 activation, but enhanced LPS induced STAT1 and STAT3 activation (XREF_FIG)."
22925925
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"LPS stimulated NF-kappaB p65 subunit nuclear translocation, visualized by immunofluorescence, was attenuated in both MS and T2DM subjects after MES+HS treatment (XREF_FIG C and XREF_FIG C)."
26137510
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"However, pretreatment with low-dose LPS downregulated the p-p65/p65 ratio, suggesting that ET prevents the triggering of the NF-κB signaling pathway induced by LPS/D-GalN."
38581992
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"Finally, we report that news SERMs, ospemifene and bazedoxifene, exert anti-inflammatory actions by a mechanism involving classical estrogen receptors and by the inhibition of LPS induced NFkappaB p65 transactivation."
19533603
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"GILZ-p Inhibits LPS Induced NF-kappaB p65 Nuclear Translocation."
29681857
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"Our results showed that LPS treatment caused the decrease of p65 and p50 in the cytoplasm and increase in nucleus, and this effect can be reversed by the pretreatment with WEL in a dose dependent manner."
24176090
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"Co-incubation with MaR1 (10 nM) significantly attenuated LPS induced NF-kappaB p65 nuclear translocation in BMDMs [nuclear p65 + cells : 16 (3)%, P < 0.01 vs LPS group, XREF_FIG a and b], and partly reduced TNF-alpha levels in the culture medium [494 (49) pg ml -1, P = 0.01 vs LPS group; XREF_FIG c]."
30770053
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"Interestingly, the autophosphorylation site Tyr-867 of MerTK is fundamental in efferocytosis but not in the reduction of LPS-induced NF-κBp65 activation ( Tibrewal et al., 2008 )."
33992683
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"Our data revealed that LPS-induced p65, c-Rel and p50, not Relb, were suppressed by co-treating cells with LPS and GD1a ( Fig. 4 )."
26054879
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"Collectively, BRD4-siRNA-LP ameliorated the LPS induced ARDS by suppressing p65 and STAT3 crosstalk."
33781885
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"These data suggest that HMGB1 and LPS stimulation could downregulate the expression NF-kappaB p65 in cytoplasmic proteins and increase the expression in nuclear proteins, thus leading to modulation of IL-1beta, IL-10, IFN-gamma, and TGF-beta expression; moreover, the suppressive function of Treg cells could be regulated by TLR4."
28096525
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"PTX similarly decreased LPS induced NF-kappaB p65 nuclear phosphorylation, a marker of NF-kappaB activation and nuclear translocation (100 +/- 0 vs. 40 +/- 6; P = 0.03; XREF_FIG)."
18568240
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"As shown in Fig. 6 b , LPS significantly increased the location of NF-κB p65 in the nuclear fractions but reduced the location of NF-κB p65 in the cytoplasmic fractions."
35597110
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"Moreover, LPS-stimulated HBEpC and HTEpC cells treated with 0.3% thyme extract showed a significant reduction of NF-kB p65, NF-kB p52 and IL-8 production when compared with LPS treated cells in both c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27369807
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"Pretreatment with 6-MP had no inhibitory effects on LPS induced p65 DNA binding, indicating that 6-MP does not change the binding of p65 to the kappaB sites in an in vitro assay."
27075886
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"Hence from the study it was concluded that the mechanism underlying PGJ2 inhibition was not through a PPAR-γ, but rather by NFκB dependent mechanism [49] .15-Deoxy-Δ 12 and Δ 14 -PGJ2 inhibited LPS in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30711851
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"In fact, IkappaB kinase (IKK) assays showed that 1,25 (OH) 2 D 3 attenuated LPS induced IkappaBalpha phosphorylation in macrophages (XREF_FIG), which explains why 1,25 (OH) 2 D 3 stabilized IkappaBalpha protein reported previously, and immunostaining confirmed that 1,25 (OH) 2 D 3 blocked LPS induced p65 nuclear translocation RAW264.7 cells (XREF_FIG)."
23436936
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"To that end, it is worth nothing that though the use of a higher oxymatrine concentration in vitro resulted in an increased inhibition of LPS induced p65 nuclear translocation, this higher concentration was also associated with cellular toxicity."
23568217
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"Our data suggest that HMGB1 and LPS stimulation could downregulate the expression NF-kappaB p65 in cytoplasmic protein and increase it in nuclear protein, thus leading to modulation of IL-1beta, IL-10, IFN-gamma, and TGF-beta expression."
28096525
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"Curcusomes reduced the level of LPS induced nuclear p65 and RelA as assessed by immunofluorescence microscopy and p65 and RelA DNA binding activity by ELISA (XREF_FIG)."
21885868
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"Curcusomes reduced the level of LPS induced nuclear p65 and RelA as assessed by immunofluorescence microscopy and p65 and RelA DNA binding activity by ELISA (XREF_FIG)."
21885868
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"In addition, LPS induced p65 nuclear translocation was significantly suppressed by NOX4 siRNA."
27891092
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"In contrast, exposure to P. gingivalis LPS and hispidulin decreased nuclear p65 (11.4%) accumulation (Figure 4b)."
37764491
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"This treatment pronouncedly alleviated LPS induced neuroinflammatory response, characterized by decreased 5LO, suppressed activation of microglia, decreased NF-kappaB p65, TNF-alpha and IL-1beta, and significantly increased the ratio of p-CREB and CREB or mBDNF and proBDNF in the hippocampus of the LPS challenged mice."
29174741
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"Overall, this experimental work documents that acenocoumarol inhibits the LPS-stimulated p65 nuclear translocation and the NF-κB signaling pathway."
36903321
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"LPS induced secretion of TNF-alpha, IL-6, IL-1beta and NO was significantly attenuated in RelA and p65 Deltamye BMMPhis compared to WT (XREF_FIG)."
23562811
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"We pre-treated the FaDu cells with a widely used NF-kB inhibitor, BAY 11–7082, before LPS stimulation to inhibit RELA."
31061469
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"LPS induced secretion of TNF-alpha, IL-6, IL-1beta and NO was significantly attenuated in RelA and p65 Deltamye BMMPhis compared to WT (XREF_FIG)."
23562811
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"Besides, restoration of FOXD1 partially abrogated LPS-induced decrease of IκBβ and activation of p65 (online supplemental figure S8C)."
30635407
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"DMPO reduces LPS induced NF-kappaB p65 translocation and IkappaBalpha degradation."
22285597
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"Using chromatin immunoprecipitation, we demonstrate that LPS induced RelA recruitment to the ICAM-1 gene promoter is significantly reduced in luteolin treated cells."
15946255
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"Taken together, our results suggested that sauchinone could inhibit production of NO in LPS stimulated RAW264.7 cells through the suppression of NF-kappaB by inhibiting transactivation activity of RelA subunit."
14750024
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"Again, by adding a universal inhibitor of caspases (z-VAD-fmk), the chymase-induced degradation of LPS-activated p65 was abolished (lane 3)."
16460729
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"In contrast, as visualized by immunocytochemistry ( Fig. 3 C), the chymase-induced degradation of LPS-activated p65 (upper right panel vs. upper left panel) was reversed in the presence of a caspase i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16460729
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"Further, while NF-kappaB p50 +/+ mice exhibited an LPS induced increase in brain NF-kappaB p65 DNA binding in both young and aging mice, the NF-kappaB p50 -/- mice revealed a decrease in LPS induced NF-kappaB p65 DNA binding, regardless of age."
30871598
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"Su et al. (2010) found that l-citronellol significantly reduces the expression of NO, PGE2, iNOS, COX-2 protein, and mRNA in macrophages induced by LPS and reverses the cytoplasmic degradation of IκBα[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32877718
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"Moreover, we elucidated that MBF-DE attenuated LPS induced inflammatory responses by blocking activation of both NF-kappaB and p65 and pERK and MAPK pathways."
26615818
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"Immunofluorescence (IF) experiments also displayed stronger green fluorescence in the LPS group and weaker fluorescence in the TRYP and BAY11-7082 groups, suggesting that TRYP could inhibit the transfer of NF-κB p65 to the nucleus (Figure 5F)."
39035974
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"Our data indicate significant suppression of LPS induced NF-kappaB p65 nuclear translocation by the cAMP elevating metabolite synaptamide in microglia cells."
27809877
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"We found that treatment with propofol significantly (p < 0.05) inhibited LPS induced NF-kappaB p65 nuclear translocation (56.7 +/-11.3 with LPS only vs. 17.7 +/-10.1 with LPS + propofol, XREF_FIG)."
21408125
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"The results were shown that the LPS + CUR, LPS + EMO and LPS + CUR/EMO groups significantly inhibited p-NF-κB p65 (Additional file 1: Fig. S6)."
37596598
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"A reduced expression of cytosolic IkappaB-alpha and NF-kappaBp65 was also observed when macrophages were treated with LPS alone or in combination with ASA."
25075522
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"Oxyimperatorin attenuates LPS-induced microglial activation in vitro and in vivo via suppressing NF-κB p65 signaling."
38452656
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"The results in Fig. 5 B demonstrate that LPS-induced p65 nuclear translocation was blocked by treatment with montelukast, thereby confirming the inhibitory effect of montelukast on NF-κB activation."
29268191
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"We therefore conclude that type I parasites do not inhibit TNF- or LPS stimulated NF-kappaB p65 translocation or TNF stimulated NF-kappaB-mediated transcription, but they may be able to modulate other pathways or host cell transcription factors which are important for expression of a small subset of TNF stimulated genes."
21199955
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"EGFR inhibition promoted LPS stimulated NF-kappaB p65 nuclear translocation (XREF_FIG)."
24391216
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"Our results indicate a reduction of approximately 50% in the amounts of nuclear p65 in DC treated with DHA and LPS, and the reduction in p65 nuclear translocation correlates with DHA mediated IkappaB stabilization."
20122166
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"Thus, these results indicated that stimulating autophagy can mitigate LPS-induced inflammatory injury in BEECs.Our findings also revealed that overexpression of A20 enhanced autophagy levels, which were hindered by LPS, concomitantly reducing the levels of p-p65 and p-IκBα, preventing p65 from entering the nucleus and ultimately inhibiting NF-κB pathway activation."
39409825
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"Unexpectedly, our results revealed that sulfasalazine (SSZ) (a NF-κB inhibitor through inhibition of IκBα degradation) prevented the trans-nucleus of NF-κB p65, but α-M-γ-B did not reverse LPS-induced IκBα degradation and nucleus entry of NF-κB p65 (Fig. 6A and Supporting Information Fig. S5)."
39220880
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"Also, LPS treatment decreased p65 ISGylation in HLMVECs (Fig. 1D)."
36994728
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"Immunofluorescence staining for p65 revealed that LPS promoted p65 nuclear translocation but MPPa-PDT reversed this effect ( Fig. 5 e)."
30562579
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"In the kidney, protein levels of phosphorylated p65 (Pp65) and total p65 were not affected by daytime LPS injection and lighting regime but the Pp65/p65 ratio was reduced by both ALAN (p < 0.05) and LPS stimulation (p < 0.05; Fig. 7c)."
37644084
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"It is clear that LPS-induced p65 was significantly inhibited in a dose-dependent manner by HDDQ ( Fig. 4 B)."
24055019
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"Compared to the control group, the addition of SC75741 significantly reduced the positive expression of RELA and p-RELA proteins in HcerEpic cells in a dose-dependent manner, indicating that SC75741 inhibited the activation of RELA by LPS (Figure 3F)."
40141137
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"Additionally, in Raw264.7 cells, pretreatment with bergenin inhibited markedly nuclear translocation and phosphorylation of NF-κB p65 induced by LPS."
28192201
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"This hypothesis was supported by our results indicating that LPS induced NF-kappaB p65 activation in GC cell was reversed when the cell was incubated with DPI (XREF_FIG)."
24030146
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"In control vector (pcDNA3.0)-treated mice, the LPS challenges (60 and 120 mg/g data were averaged, because the responses were similar) decreased NFkB p50 and p65 protein in the lung homogenate nuclear preparations."
15700545
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"In addition, neither SB203580 nor SP600125 showed inhibitory effect on LPS-induced p65 activation."
29906494
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"The density ratio of LPS-induced p65 was significantly reduced in a concentration-dependent manner by TMC."
23566812
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"It is clear that the density ratio of LPS-induced p65 was significantly inhibited in a dose-dependent manner by sulfuretin ( Fig. 4 A)."
20450988
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"As shown in XREF_FIG, LPS induced p65 nuclear translocation was significantly blocked in GRK5 -/- cells compared to GRK5 +/+ macrophages (XREF_FIG)."
20945396
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"Moreover, the enhancement of stat3 phosphorylation and decrease of LPS induced p65 translocation were achieved by nicotine treatment."
28766689
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"Inhibition of LPS induced p65 translocation has been reported in human monocytes treated with ethanol in vitro, but decreased phosphorylation of p65 (which was not assessed in the present study) was found to be more important [XREF_BIBR]."
19765273
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"We further found that LPS-induced p65 translocation was reduced after 25 μM SFN pretreatment from 30 minutes to 12 hours, but that a prolonged pretreatment of these cells with SFN for more than 12 hou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18248854
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"The addition of LPS (100 ng/mL, 15 min) significantly increased and decreased the nuclear content of p50 and RelA and p50 and p50, respectively (XREF_FIG)."
25184316
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"We conclude that LPS tolerance disrupts the transactivating stage of NF-kappaB p65 and altered nucleosome remodeling at the IL-1beta promoter in human leukocytes."
15972680
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"By introducing MGF and MGF SA treatment at a concentration of 500 mg/L, significant inhibition of the LPS-induced NF-κB p65 nuclear migration was possible."
38279104
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"Pretreatment with KPG showed a decrease in LPS induced nuclear localization of the p65 subunit in a concentration dependent manner."
29470957
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"In addition, we find that ECs treated with BSO to reduce intracellular GSH levels facilitate the inhibitory effects of SFN in LPS-induced p65 translocation and IκB degradation."
18248854
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"The diarylpentadienone derivatives of curcumin inhibit LPS-induced inducible nitric oxide synthase (iNOS) expression, and slightly reduces the activation of p65 in nuclei [55]."
30347782
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"PDTC Diminished LPS Induced NF-kappaB p65 Activity in the Hippocampus."
27493629
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"Finally, nuclear translocation of NF-κB p65 was detected by immunofluorescence, and it was found that LPS inhibited p65 activity in cells, while morphine induced p65 activity and nuclear translocation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35643178
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"The results showed that IκB-α degradation and p65 activation induced by LPS were significantly inhibited by Rg1, which suggests that Rg1 suppressed excessive cytokine production by inhibiting NF-κB ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26122136
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"The LPS induced p65 translocation was inhibited by EP treatment."
20026271
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"We also found both IL-6-induced STAT3 phosphorylation and LPS-induced p65 translocation were reduced after 25 μM chalcone pretreatment from 30 min to 3 h."
17320913
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"The Western blot assay results show that xanthotoxol suppresses LPS-induced p65 translocation from cytosol to the nucleus in RAW 264.7 cells."
35628627
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"PITC inhibited LPS induced IkappaBalpha phosphorylation and degradation and subsequently reduced LPS induced p65 nuclear translocation and the transcriptional activity of nuclear factor-kappaB (NF-kappaB), which was accompanied by a reduction in ERK1/2 and AKT phosphorylation."
21303260
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"It is clear that the density ratio of LPS-induced p65 was significantly ( P < 0.01) inhibited in a dose-dependent manner by SDEE in the quantitative determination ( Fig. 4 B)."
18060707
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"We also observed from our present experiments that other phenolic flavonoids, quercetin and cyanidin, which lack α,β-unsaturated carbonyl group showed weaker or no effect in inhibition of both IL-6-in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17320913
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"Inhibition of LPS induced NF-kappaB p65 nuclear translocation was confirmed by immunoblotting (data not shown)."
21257959
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"Evodiamine Relieve LPS Induced Mastitis by Inhibiting AKT and NF-kappaB p65 and MAPK Signaling Pathways."
34401976
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"LPS-induced p65 translocation was significantly blocked by siPoldip2 (Fig. 5b)."
31779628
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"As shown in Figures 6(c) and 6(d), LPS stimulation caused p65 to shift to the nucleus and ZBSO treatment effectively blocked the nuclear accumulation of p65 induced by LPS."
34603465
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"However, while LPS treatment alone elevated p65 in both cytoplasmic and nuclear compartments, and pre-treatment with ghrelin and [D-Lys3]-GHRP-6 attenuated p65, there was no apparent alteration in the cytoplasmic to nuclear ratio to indicate regulation via p65."
23509933
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"Pretreatment with the hydroxyestrogen 2-OHE2 had minimal effects on NFκB binding, as only 13% of LPS-induced p65 binding peaks were significantly reduced in read density."
34031590
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"In control vector (pcDNA3.0)-treated mice, the LPS challenges (60 and 120 mg/g data were averaged, because the responses were similar) decreased NFkB p50 and p65 protein in the nuclear preparations in lung Intratracheal Plasmid DNA and LPS Lung Injury665Downloaded by [University of Wisconsin - Madison] at 00:54 16 December 2017FIGURE 5 Ribonuclease protection assay showing lung cytokine mRNA profiles after vector pretreatments and LPS challenges."
15700545
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"In summary, MSC derived exosomal miR-27b inhibited LPS induced pro inflammatory effects on BMDMs by inhibiting JMJD3 and NF-kappaB and p65 axis."
33413595
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"They also found that miR-21 attenuated production of pro-inflammatory cytokines TNF-α and IL-6 in LPS-stimulated peritoneal macrophages and reduced activation of the NF-κB p65 protein in bone marrow-derived macrophages."
29172874
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"This observation was supported by another ChIP assay where LPS induced p65 recruitment on the same NF-kappaB RE of TNF-URR was significantly reduced by rosi treatment but not with cardiolipin (XREF_FIG, left panel)."
28074841
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"A decrease of cytosolic IkappaB-alpha expression and increased nuclear translocation of NF-kappaBp65 was also observed when HepG2 cells were treated with LPS alone or in combination with ASA."
27441638
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"However, LPS induced p65 translocation was significantly reduced in cells pre-treated with NRG-1 followed by LPS using ELISA and western blot."
27596278
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"Maximal inhibition of LPS induced NF-kappaB p65 activation was achieved with 11,12-EET, followed by 14,15-EET and 8,9-EET, indicating differential bioactivity of the different EET regioisomers, while all kinds of EETs had no obvious effect on LPS induced c-Rel activation."
25626689
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"Inhibition of LPS induced nuclear localization of p65 by ATF3."
26412238
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"Moreover, both basal and LPS induced NF-kappaBp65 activity was significantly reduced following exposure to acrolein compared with exposure to room air."
18566440
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"In Study 102, LPS stimulated p65 activity was reduced for 5 of 8 subjects receiving 14 days of edasalonexent treatment (4000 mg daily) but not in 3 subjects receiving placebo."
28074489
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"However, it is unknown why there is only a partial inhibition of p120 on NF-kappaB activation and p65 was still found in nucleus in pEGFPp120 cells treated with LPS."
20172018
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"P53 inhibition in CAIA and LPS treated PARK2 KO mice increased p50 and p65 nuclear localization and NF-kappaB activation."
28395174
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"We found that propofol treatment significantly (p < 0.05) reduced LPS induced NF-kappaB p65 nuclear translocation (47.3 +/-10.2 with LPS only vs. 17.1 +/-4.5 with LPS + propofol, XREF_FIG)."
21408125
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"Aqp9 Deletion Reduces NF-kappaB p65 Elevation by LPS."
| PMC
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"In addition , TNF-alpha , IL-1beta , MyD88 , MMP-3 , TLR4 , and NF-kappaB p65 were significantly upregulated by LPS , but suppressed by BZD treatment ( Figure 2 ) ."
33912052
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"WTQR and GD may decrease the MIP-2 and NO/iNOS signaling through the suppression of TNF-α production in GalN/LPS-treated mice and LPS-stimulated RAW264 macrophages.WTQR and GD decreased the nuclear NF[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22154906
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"Since HDAC1 silencing exerts no significant effect on either miR-146a and miR-155 expression or redistribution of H3K4me3, it appears that LPS mediated NF-kappaB p65 and NF-kappaB p50 do not form repressor complexes with HDAC1."
24699235
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"In our study, LPS induced degradation of IkappaB-alpha and NF-kappaBp65 nuclear localization in BMDCs from Wnt5aCAGDelta and Delta and Ror2 MxDelta and Delta mice, as well as BMDCs from control mice."
26030277
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"In LPS-treated microglial cells, CBD interfered with NF-κB by reducing phosphorylated-p65 (RelA), a subunit of NF-κB, below control levels [24] ."
38245915
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"Strikingly, RelA recruitment to target gene promoters was blocked when cells were treated with LPS in the presence of AICAR."
29773845
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"LPS enhanced p65 nuclear translocation in macrophages; however, LPS induced p65 translocation was attenuated with the HO-1 activator CoPP (XREF_FIG)."
24003391
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"Taken together, these results demonstrate that the induction of HO-1 has an inhibitory effect on LPS induced COX-2 expression through the attenuation of LPS induced p65 translocation."
24003391
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"MS-275 inhibited LPS induced NF-kappaB p65 nuclear accumulation in human fibroblastic cells, gave rise to less acetylated NF-kappaB p65 in the nucleus, and reduced the secretion of pro inflammatory cytokines IL-6 and IL-18 XREF_BIBR."
28344354
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"In our study of RAW264.7 cells, we suggested that the nuclear translocation of LPS induced NF-kappaB p65 was significantly inhibited by nicotine treatment, which may indicate the modulation of nicotine treatment on macrophages in ICM rat."
28928157
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"However, consistent with a recent report, we were not able to detect LPS-induced degradation of p65 in peritoneal macrophages and bone marrow-derived macrophages ( Li et al., 2005 )."
16413922
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"More importantly, lincRNA-p21 inhibition showed a negative effect on LPS induced p65 nuclear translocation and NF-jB activation."
32362153
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"However, we could detect LPS-induced p65 degradation in the RAW264.7 macrophage cell line."
16413922
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"TNF-α and LPS treatments attenuated phospho-NF-κB (p65) levels in EC-iDKO MAECs (Figure 1A,B and Supplementary Materials Figure S2A,B)."
34440686
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"Results showed that the nuclear expression levels of NF-κB p65 were dramatically increased in the LPS stimulation compared with control group, while flavonols pretreatment inhibited the LPS-induced nuclear accumulation of NF-κB p65."
35941847
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"XI also markedly alleviated LPS-induced reduction of cytoplasmic p65."
38027703
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"In these cells, when constitutively expressed IκBNS, LPS-induced p65 turnover was accelerated, indicating that IκBNS is involved in the degradation of promoter-bound p65."
16413922
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"Inhibitory effect of acetylcorynoline on LPS induced NF-kappaB p65 translocation."
23472193
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"Besides this, the phosphorylation levels of IκBα and NF-κB p65 in the kidneys of the MaR1 group were obviously lower than those of the LPS group (both p <0.0001) (Figures 4E,F), which suggested that MaR1 could inhibit the activated NF-κB p65 pathways."
34955852
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"Remarkably, total NF-kappaB p65 protein content was significantly reduced by 30% in LPS and IFNgamma stimulated RAW264.7 macrophages treated with MS-275 (XREF_FIG)."
28344354
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"LPS markedly translocated NF-κB p65 to the nucleus, whereas pre-treatment with AAL suppressed the translocation of NF-κB p65 ( Fig. 5 A)."
32014631
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"Similarly, co-treatment of LPS-induced macrophages with DAPA (0.5 μM) could reduce 51.9% and 34.5% of p–NF–kB p65 under NG and HG conditions, respectively.One of the main consequences of activation of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35026193
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"Our data revealed that LPS induced the up-regulation of ICAM-1, MCP-1 and TNF-alpha, LPS induced the down-regulation of PPARgamma, and LPS enhanced NF-kappaB p65 activation and DNA binding activity were substantially suppressed by emdoin in RAW264.7 cells."
26910236
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"Therefore, the LPS-induced p65 nuclear translocation in macrophages was suppressed by miR-34a overexpression."
22483937
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"In contrast, MS-275 was previously shown to inhibit LPS induced NF-kappaB p65 nuclear accumulation and acetylation XREF_BIBR."
28344354
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"However, the 10 or 50 μg/mL AGWE combined with LPS significantly decreased the level of NF-κB (p65) translocated (31–38%) compared with that in the LPS-induced group (as shown in Figure 6(D))."
39670672
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"At 24 h, relative to the CONTR pigs, LPS challenge decreased mRNA abundance of liver TLR4, MyD88, IRAK1, TRAF6, NOD1, NOD2, RIPK2 and NF-κB p65 ( P <.05)."
24767309
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"Naloxone and methylprednisolone significantly reduced the LPS induced increase in IL-8 concentrations in serum in vivo, and suppressed the activation of NF-kappaB p65 in the lung tissue."
15970107
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"We also investigated the inhibitory effect of AAE on LPS-induced p65 translocation."
34271112
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"This study displayed that the ROS levels and expressions of phosphorylation of IκBα and p65 in the MaR1 group were significantly reduced compared with the LPS group, which indicated that MaR1 could inhibit the production of ROS and the activation of the NF-κB p65 pathway."
34955852
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"PB and PD98059/SP600125 caused additive inhibitory effects on LPS-induced p65 NF-κB, AP-1, and STAT1/3 activation, indicating that ERK and JNK were the upstream signaling molecules involved in the inh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32593157
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"While our observations offer no single mode of action associated treatment, one can speculate that inhibition of NF-kappabeta activation and signaling is involved, which is supported by the observed suppression of LPS stimulated p65 in qPCR assays."
25843059
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"Moreover, both p65 nuclear translocation and NF-jB activity were promoted by lincRNA-p21 overexpression, while lincRNA-p21 inhibition showed a negative effect on LPS induced p65 nuclear translocation and increase of NF-jB activity."
32362153
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"Chromatin immunoprecipitation assay demonstrated that LPS induced RelA recruitment to the ICAM-1 gene promoter was inhibited by SME."
15996193
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"It was observed that LQJD reduced the LPS-induced body temperature, inflammatory cytokines level, and lung injuries, and blocked the activation of TLR4/NF-kappaBp65 signaling in lung tissue."
28972887
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"Next, the RAW264.7 and BMDM cells were exposed to LPS with or without baicalin for 24 h to further confirm whether baicalin could inhibit macrophage SIRT1 and its downstream p65 NF-κB pathway in vitro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38762213
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"LPS induced p65 binding was significantly reduced at 74 IL-4-repressed enhancers, while IL-4-repressed inflammatory response was not associated with modulated p65 binding at 374 enhancers (XREF_FIG E and 6F)."
29343442
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"Here, we also showed that LPS-promoted p65 nucleation was significantly suppressed when treated with EsA, highlighting that EsA played its protective role in UC via regulating NF-κB pathway."
35965809
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"Inhibitory effect of LZ-207 on LPS induced NF-kappaB p65 activation in HCT116 cells."
26023926
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"Suppression of LPS stimulated NF-kappaB p65 and JNK activation by BPs in macrophages."
24167596
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"Treatment of JSH-23 compound to LPS-stimulated RAW 264.7 cells decreased nuclear content of NF-κB p65 in a dose-dependent manner, corresponding to 49 ± 4% inhibition at 3 μM, 75 ± 7% at 10 μM and 95 ±[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15280016
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"Densitometric analysis for N = 3 independent protein extracts, normalized to β-actin, confirms that LPS decreased cytosolic NF-κB p65 ( p < 0.05, Kruskal–Wallis ANOVA, followed by Dunns’ multiple comp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21195213
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"When p100 expression is high due to BCR stimulated RelA and cRel activity, the latter mechanism might lead to post-induction repression of cRel akin to IkappaBdelta mediated repression of lipopolysaccharide induced RelA activity in mouse embryonic fibroblasts (MEFs)."
25497099
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"We also found that Sirt7 deficiency in mouse aortic smooth muscle cells led to the suppression of lipopolysaccharide induced p65 nuclear accumulation (unpublished data)."
29651144
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"However, the same pattern was not observed in the siRNA group, in which LPS did not decrease cytoplasmic RelA but exhibited similar levels to the other siRNA groups."
28687727
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"Moreover, wedelolactone also inhibited LPS induced NF-kappaB p65 activation via the degradation and phosphorylation of IkappaB-alpha and subsequent translocation of the NF-kappaB p65 subunit to the nucleus [XREF_BIBR]."
27355071
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"However, when cells were treated with beeswax alcohol and RW0117 for 2 h and then treated with LPS, it was confirmed that the nuclear translocation of p65 was suppressed compared to that observed in the group treated with LPS alone."
33572173
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"In addition, CME affected the RAW264.7 cell cycle and inhibited the protein expressions of COX-2 and NLRP3 and prevented the phosphorylation of NF-kappaB p65 in RAW264.7 cells treated with LPS."
30379164
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"By performing ChIP-qPCR on the selected IL-4-reduced p65 binding associated enhancers, we confirmed that IL-4-dependent reduction of LPS induced p65 binding was completely abolished in the absence of STAT6 (XREF_SUPPLEMENTARY B)."
29343442
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"Inhibitory effect of LZ-207 on LPS induced NF-kappaB p65 activation in THP-1 cells."
26023926
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"Pre-treatment with oxymatrine followed by LPS stimulation resulted in a statistically significant reduction in LPS induced p65 nuclear accumulation compared to LPS-only treated cells (~ 40%; p < 0.01) (XREF_FIG)."
23568217
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"LPS also reduced cytoplasmic NF-kappaB p65 while elevated nuclear NF-kappaB p65 (P < 0.01, Figure XREF_FIG, XREF_FIG), indicating that LPS stimulated nuclear translocation of p65 and activated NF-kappaB signaling."
28415764
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"Chromatin immunoprecipitation analysis revealed that B. vulgatus and LPS induced RelA recruitment to the IL-6 promoter is inhibited by TGF-beta1 treatment."
12672795
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"RC intervention in LPS-induced RAW264.7 cells significantly reduced the expression levels of inflammatory factors tumor necrosis factor-α, interleukins-6, iNOS, and CD-86 at the messenger RNA and protein levels, downregulated IκB, p65 protein phosphorylation levels, and significantly inhibited IκB/NF-κB signaling pathway activation."
37850620
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"Additionally, immunofluorescence analysis confirmed liquiritin's inhibition of LPS-induced p65 nuclear translocation."
38767463
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"However, these LPS induced p65 protein level changes were attenuated in the HSYA groups."
23160090