IndraLab

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Lipopolysaccharide inhibits RELA. 109 / 109
2 | 1 106
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"Our results showed that LPS treatment caused the decrease of p65 and p50 in the cytoplasm and increase in nucleus, and this effect can be reversed by the pretreatment with WEL in a dose dependent manner."
24176090
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"Evodiamine Relieve LPS Induced Mastitis by Inhibiting AKT and NF-kappaB p65 and MAPK Signaling Pathways."
34401976
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"LPS induced secretion of TNF-alpha, IL-6, IL-1beta and NO was significantly attenuated in RelA and p65 Deltamye BMMPhis compared to WT (XREF_FIG)."
23562811
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"Our results indicate a reduction of approximately 50% in the amounts of nuclear p65 in DC treated with DHA and LPS, and the reduction in p65 nuclear translocation correlates with DHA mediated IkappaB stabilization."
20122166
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"The Western blot assay results show that xanthotoxol suppresses LPS-induced p65 translocation from cytosol to the nucleus in RAW 264.7 cells."
35628627
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"Other flavonoids, quercetin and cyanidin, which lack alpha,beta-unsaturated carbonyl group, showed weaker or no inhibitory effect on both IL-6-induced STAT3 phosphorylation and LPS induced p65 translocation."
17320913
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"Moreover, the enhancement of stat3 phosphorylation and decrease of LPS induced p65 translocation were achieved by nicotine treatment."
28766689
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"We conclude that LPS tolerance disrupts the transactivating stage of NF-kappaB p65 and altered nucleosome remodeling at the IL-1beta promoter in human leukocytes."
15972680
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"Inhibition of LPS induced NF-kappaB p65 nuclear translocation was confirmed by immunoblotting (data not shown)."
21257959
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"By performing ChIP-qPCR on the selected IL-4-reduced p65 binding associated enhancers, we confirmed that IL-4-dependent reduction of LPS induced p65 binding was completely abolished in the absence of STAT6 (XREF_SUPPLEMENTARY B)."
29343442
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"Moreover, we elucidated that MBF-DE attenuated LPS induced inflammatory responses by blocking activation of both NF-kappaB and p65 and pERK and MAPK pathways."
26615818
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"Besides this, the phosphorylation levels of IκBα and NF-κB p65 in the kidneys of the MaR1 group were obviously lower than those of the LPS group (both p <0.0001) (Figures 4E,F), which suggested that MaR1 could inhibit the activated NF-κB p65 pathways."
34955852
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"In our study, LPS induced degradation of IkappaB-alpha and NF-kappaBp65 nuclear localization in BMDCs from Wnt5aCAGDelta and Delta and Ror2 MxDelta and Delta mice, as well as BMDCs from control mice."
26030277
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"Curcusomes reduced the level of LPS induced nuclear p65 and RelA as assessed by immunofluorescence microscopy and p65 and RelA DNA binding activity by ELISA (XREF_FIG)."
21885868
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"In summary, MSC derived exosomal miR-27b inhibited LPS induced pro inflammatory effects on BMDMs by inhibiting JMJD3 and NF-kappaB and p65 axis."
33413595
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"Chromatin immunoprecipitation revealed that LPS challenge decreased p65, increased p50 and p52, and had no effect on RelB and c-Rel binding to kappaB elements of the AQP2 promoter."
18703515
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"Moreover, both p65 nuclear translocation and NF-kappaB activity were promoted by lincRNA-p21 overexpression, while lincRNA-p21 inhibition showed a negative effect on LPS induced p65 nuclear translocation and increase of NF-kappaB activity."
32362153
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"In Study 102, LPS stimulated p65 activity was reduced for 5 of 8 subjects receiving 14 days of edasalonexent treatment (4000 mg daily) but not in 3 subjects receiving placebo."
28074489
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"Pretreatment with KPG showed a decrease in LPS induced nuclear localization of the p65 subunit in a concentration dependent manner."
29470957
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"Pretreatment with the hydroxyestrogen 2-OHE2 had minimal effects on NFκB binding, as only 13% of LPS-induced p65 binding peaks were significantly reduced in read density."
34031590
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"Aqp9 Deletion Reduces NF-kappaB p65 Elevation by LPS."
| PMC
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"However, it is unknown why there is only a partial inhibition of p120 on NF-kappaB activation and p65 was still found in nucleus in pEGFPp120 cells treated with LPS."
20172018
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"Maximal inhibition of LPS induced NF-kappaB p65 activation was achieved with 11,12-EET, followed by 14,15-EET and 8,9-EET, indicating differential bioactivity of the different EET regioisomers, while all kinds of EETs had no obvious effect on LPS induced c-Rel activation."
25626689
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"We therefore conclude that type I parasites do not inhibit TNF- or LPS stimulated NF-kappaB p65 translocation or TNF stimulated NF-kappaB-mediated transcription, but they may be able to modulate other pathways or host cell transcription factors which are important for expression of a small subset of TNF stimulated genes."
21199955
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"This observation was supported by another ChIP assay where LPS induced p65 recruitment on the same NF-kappaB RE of TNF-URR was significantly reduced by rosi treatment but not with cardiolipin (XREF_FIG, left panel)."
28074841
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"To that end, it is worth nothing that though the use of a higher oxymatrine concentration in vitro resulted in an increased inhibition of LPS induced p65 nuclear translocation, this higher concentration was also associated with cellular toxicity."
23568217
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"Inhibitory effect of acetylcorynoline on LPS induced NF-kappaB p65 translocation."
23472193
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"In our study of RAW264.7 cells, we suggested that the nuclear translocation of LPS induced NF-kappaB p65 was significantly inhibited by nicotine treatment, which may indicate the modulation of nicotine treatment on macrophages in ICM rat."
28928157
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"P53 inhibition in CAIA and LPS treated PARK2 KO mice increased p50 and p65 nuclear localization and NF-kappaB activation."
28395174
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"However, the same pattern was not observed in the siRNA group, in which LPS did not decrease cytoplasmic RelA but exhibited similar levels to the other siRNA groups."
28687727
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"Our data indicate significant suppression of LPS induced NF-kappaB p65 nuclear translocation by the cAMP elevating metabolite synaptamide in microglia cells."
27809877
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"These effects were correlated to a suppression of LPS-mediated p65 activation, the critical transactivation subunit for NF-κB transcription factor."
36948263
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"In contrast, MS-275 was previously shown to inhibit LPS induced NF-kappaB p65 nuclear accumulation and acetylation XREF_BIBR."
28344354
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"This hypothesis was supported by our results indicating that LPS induced NF-kappaB p65 activation in GC cell was reversed when the cell was incubated with DPI (XREF_FIG)."
24030146
ctd
No evidence text available
21948866
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"We pre-treated the FaDu cells with a widely used NF-kB inhibitor, BAY 11–7082, before LPS stimulation to inhibit RELA."
31061469
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"EF inhibited the LPS induced NF-kappaB p65 (LPS+EF 20mug/mL and 30mug/mL vs. LPS only : 0.78 +/-0.06 vs. 1.17 +/-0.08, P < 0.001; and 0.90 +/-0.06 vs. 1.17 +/-0.08, P = 0.002) and inhibitor of kappa B (IkappaBalpha) phosphorylation (LPS+EF 20mug/mL and 30mug/mL vs. LPS only : 0.25 +/-0.01 vs. 0.63 +/-0.03, P < 0.001; and 0.31 +/-0.01 vs. 0.63 +/-0.03, P < 0.001), LPS+EF 30mug/mL inhibited IkappaB kinase (IKKalpha and beta) phosphorylation (LPS+EF 30mug/mL vs. LPS only, 1.12 +/-0.14 vs. 1.71 +/-0.25, P = 0.002) in RAW 264.7 cells."
30681498
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"It was observed that LQJD reduced the LPS induced body temperature, inflammatory cytokines level, and lung injuries, and blocked the activation of TLR4 and NF-kappaBp 65 signaling in lung tissue."
28972887
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"PITC inhibited LPS induced IkappaBalpha phosphorylation and degradation and subsequently reduced LPS induced p65 nuclear translocation and the transcriptional activity of nuclear factor-kappaB (NF-kappaB), which was accompanied by a reduction in ERK1/2 and AKT phosphorylation."
21303260
eidos
"In addition , TNF-alpha , IL-1beta , MyD88 , MMP-3 , TLR4 , and NF-kappaB p65 were significantly upregulated by LPS , but suppressed by BZD treatment ( Figure 2 ) ."
33912052
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"Inhibition of LPS induced p65 translocation has been reported in human monocytes treated with ethanol in vitro, but decreased phosphorylation of p65 (which was not assessed in the present study) was found to be more important [XREF_BIBR]."
19765273
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"Co-incubation with MaR1 (10 nM) significantly attenuated LPS induced NF-kappaB p65 nuclear translocation in BMDMs [nuclear p65 + cells : 16 (3)%, P < 0.01 vs LPS group, XREF_FIG a and b], and partly reduced TNF-alpha levels in the culture medium [494 (49) pg ml -1, P = 0.01 vs LPS group; XREF_FIG c]."
30770053
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"Further, while NF-kappaB p50 +/+ mice exhibited an LPS induced increase in brain NF-kappaB p65 DNA binding in both young and aging mice, the NF-kappaB p50 -/- mice revealed a decrease in LPS induced NF-kappaB p65 DNA binding, regardless of age."
30871598
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"Curcusomes reduced the level of LPS induced nuclear p65 and RelA as assessed by immunofluorescence microscopy and p65 and RelA DNA binding activity by ELISA (XREF_FIG)."
21885868
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"Moreover, both basal and LPS induced NF-kappaBp65 activity was significantly reduced following exposure to acrolein compared with exposure to room air."
18566440
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"Collectively, BRD4-siRNA-LP ameliorated the LPS induced ARDS by suppressing p65 and STAT3 crosstalk."
33781885
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"LPS up-regulated p65 was dramatically inhibited at 3 h, but was enhanced at 6 h by SFN pre-incubation in porcine moDCs (XREF_FIG)."
25793534
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"A decrease of cytosolic IkappaB-alpha expression and increased nuclear translocation of NF-kappaBp65 was also observed when HepG2 cells were treated with LPS alone or in combination with ASA."
27441638
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"LPS induced secretion of TNF-alpha, IL-6, IL-1beta and NO was significantly attenuated in RelA and p65 Deltamye BMMPhis compared to WT (XREF_FIG)."
23562811
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"However, when cells were treated with beeswax alcohol and RW0117 for 2 h and then treated with LPS, it was confirmed that the nuclear translocation of p65 was suppressed compared to that observed in the group treated with LPS alone."
33572173
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"In addition, MSL significantly inhibited nuclear translocation of NF-kappaB p65 in cells treated with LPS in vitro."
27620503
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"As shown in XREF_FIG, LPS induced p65 nuclear translocation was significantly blocked in GRK5 -/- cells compared to GRK5 +/+ macrophages (XREF_FIG)."
20945396
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"Taken together, our results suggested that sauchinone could inhibit production of NO in LPS stimulated RAW264.7 cells through the suppression of NF-kappaB by inhibiting transactivation activity of RelA subunit."
14750024
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"GILZ-p Inhibits LPS Induced NF-kappaB p65 Nuclear Translocation."
29681857
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"XREF_BIBR, who demonstrated that Ni 2+ ions inhibited LPS induced p65 binding to DNA in a human monocyte cell line."
23844176
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"The LPS induced p65 translocation was inhibited by EP treatment."
20026271
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"This study displayed that the ROS levels and expressions of phosphorylation of IκBα and p65 in the MaR1 group were significantly reduced compared with the LPS group, which indicated that MaR1 could inhibit the production of ROS and the activation of the NF-κB p65 pathway."
34955852
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"When p100 expression is high due to BCR stimulated RelA and cRel activity, the latter mechanism might lead to post-induction repression of cRel akin to IkappaBdelta mediated repression of lipopolysaccharide induced RelA activity in mouse embryonic fibroblasts (MEFs)."
25497099
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"TNF-α and LPS treatments attenuated phospho-NF-κB (p65) levels in EC-iDKO MAECs (Figure 1A,B and Supplementary Materials Figure S2A,B)."
34440686
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"(A-C) Treatment with Imp α5-selective NTM, cSN50.1α inhibits nuclear import of SRTFs: NF-κB RelA (A), phosphorylated STAT1 (B), and component of AP-1 complex, cFos (C) in LPS-stimulated RAW cells."
34099795
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"As shown in Figures 6(c) and 6(d), LPS stimulation caused p65 to shift to the nucleus and ZBSO treatment effectively blocked the nuclear accumulation of p65 induced by LPS."
34603465
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"LPS-induced p65 translocation was significantly blocked by siPoldip2 (Fig. 5b)."
31779628
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"In addition, LPS induced p65 nuclear translocation was significantly suppressed by NOX4 siRNA."
27891092
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"Taken together, these results demonstrate that the induction of HO-1 has an inhibitory effect on LPS induced COX-2 expression through the attenuation of LPS induced p65 translocation."
24003391
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"This treatment pronouncedly alleviated LPS induced neuroinflammatory response, characterized by decreased 5LO, suppressed activation of microglia, decreased NF-kappaB p65, TNF-alpha and IL-1beta, and significantly increased the ratio of p-CREB and CREB or mBDNF and proBDNF in the hippocampus of the LPS challenged mice."
29174741
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"Finally, we report that news SERMs, ospemifene and bazedoxifene, exert anti-inflammatory actions by a mechanism involving classical estrogen receptors and by the inhibition of LPS induced NFkappaB p65 transactivation."
19533603
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"The diarylpentadienone derivatives of curcumin inhibit LPS-induced inducible nitric oxide synthase (iNOS) expression, and slightly reduces the activation of p65 in nuclei [55]."
30347782
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"LPS also reduced cytoplasmic NF-kappaB p65 while elevated nuclear NF-kappaB p65 (P < 0.01, Figure XREF_FIG, XREF_FIG), indicating that LPS stimulated nuclear translocation of p65 and activated NF-kappaB signaling."
28415764
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"Furthermore, Figure 8 also shows that the degradation of IκB and phosphorylation levels of p65 induced by LPS were inhibited by TFE in a dose-dependent manner."
29725269
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"In fact, IkappaB kinase (IKK) assays showed that 1,25 (OH) 2 D 3 attenuated LPS induced IkappaBalpha phosphorylation in macrophages (XREF_FIG), which explains why 1,25 (OH) 2 D 3 stabilized IkappaBalpha protein reported previously, and immunostaining confirmed that 1,25 (OH) 2 D 3 blocked LPS induced p65 nuclear translocation RAW264.7 cells (XREF_FIG)."
23436936
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"We found that propofol treatment significantly (p < 0.05) reduced LPS induced NF-kappaB p65 nuclear translocation (47.3 +/-10.2 with LPS only vs. 17.1 +/-4.5 with LPS + propofol, XREF_FIG)."
21408125
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"PTX similarly decreased LPS induced NF-kappaB p65 nuclear phosphorylation, a marker of NF-kappaB activation and nuclear translocation (100 +/- 0 vs. 40 +/- 6; P = 0.03; XREF_FIG)."
18568240
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"LPS stimulated NF-kappaB p65 subunit nuclear translocation, visualized by immunofluorescence, was attenuated in both MS and T2DM subjects after MES+HS treatment (XREF_FIG C and XREF_FIG C)."
26137510
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"Our data revealed that LPS induced the up-regulation of ICAM-1, MCP-1 and TNF-alpha, LPS induced the down-regulation of PPARgamma, and LPS enhanced NF-kappaB p65 activation and DNA binding activity were substantially suppressed by emdoin in RAW264.7 cells."
26910236
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"However, LPS induced p65 translocation was significantly reduced in cells pre-treated with NRG-1 followed by LPS using ELISA and western blot."
27596278
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"In addition, CME affected the RAW264.7 cell cycle and inhibited the protein expressions of COX-2 and NLRP3 and prevented the phosphorylation of NF-kappaB p65 in RAW264.7 cells treated with LPS."
30379164
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"Pre-treatment with oxymatrine followed by LPS stimulation resulted in a statistically significant reduction in LPS induced p65 nuclear accumulation compared to LPS-only treated cells (~ 40%; p < 0.01) (XREF_FIG)."
23568217
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"MS-275 inhibited LPS induced NF-kappaB p65 nuclear accumulation in human fibroblastic cells, gave rise to less acetylated NF-kappaB p65 in the nucleus, and reduced the secretion of pro inflammatory cytokines IL-6 and IL-18 XREF_BIBR."
28344354
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"Inhibitory effect of LZ-207 on LPS induced NF-kappaB p65 activation in THP-1 cells."
26023926
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"Deletion of SOCS3 had no effect on LPS induced NF-kappaB p65 and ERK1/2 activation, but enhanced LPS induced STAT1 and STAT3 activation (XREF_FIG)."
22925925
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"The addition of LPS (100 ng/mL, 15 min) significantly increased and decreased the nuclear content of p50 and RelA and p50 and p50, respectively (XREF_FIG)."
25184316
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"While our observations offer no single mode of action associated treatment, one can speculate that inhibition of NF-kappabeta activation and signaling is involved, which is supported by the observed suppression of LPS stimulated p65 in qPCR assays."
25843059
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"Strikingly, RelA recruitment to target gene promoters was blocked when cells were treated with LPS in the presence of AICAR."
29773845
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"LPS enhanced p65 nuclear translocation in macrophages; however, LPS induced p65 translocation was attenuated with the HO-1 activator CoPP (XREF_FIG)."
24003391
ctd
No evidence text available
22363816
reach
"Moreover, wedelolactone also inhibited LPS induced NF-kappaB p65 activation via the degradation and phosphorylation of IkappaB-alpha and subsequent translocation of the NF-kappaB p65 subunit to the nucleus [XREF_BIBR]."
27355071
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"DMPO reduces LPS induced NF-kappaB p65 translocation and IkappaBalpha degradation."
22285597
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"A reduced expression of cytosolic IkappaB-alpha and NF-kappaBp65 was also observed when macrophages were treated with LPS alone or in combination with ASA."
25075522
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"However, while LPS treatment alone elevated p65 in both cytoplasmic and nuclear compartments, and pre-treatment with ghrelin and [D-Lys3]-GHRP-6 attenuated p65, there was no apparent alteration in the cytoplasmic to nuclear ratio to indicate regulation via p65."
23509933
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"We also found that Sirt7 deficiency in mouse aortic smooth muscle cells led to the suppression of lipopolysaccharide induced p65 nuclear accumulation (unpublished data)."
29651144
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"Since HDAC1 silencing exerts no significant effect on either miR-146a and miR-155 expression or redistribution of H3K4me3, it appears that LPS mediated NF-kappaB p65 and NF-kappaB p50 do not form repressor complexes with HDAC1."
24699235
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"Pretreatment with 6-MP had no inhibitory effects on LPS induced p65 DNA binding, indicating that 6-MP does not change the binding of p65 to the kappaB sites in an in vitro assay."
27075886
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"These data suggest that HMGB1 and LPS stimulation could downregulate the expression NF-kappaB p65 in cytoplasmic proteins and increase the expression in nuclear proteins, thus leading to modulation of IL-1beta, IL-10, IFN-gamma, and TGF-beta expression; moreover, the suppressive function of Treg cells could be regulated by TLR4."
28096525
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"While ATP levels were unchanged, the nuclear factor NF-kappaB (p65) activity was inhibited in Kupffer cells treated with MP after LPS stimulation (35.6 RLU versus 49.6 RLU in control)."
15840433
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"Interestingly, fenofibrate resulted in a strong interaction between SHP and the NF-kappaB subunit p65, which was reduced by LPS stimulation (XREF_FIG)."
23704907
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"LPS induced p65 binding was significantly reduced at 74 IL-4-repressed enhancers, while IL-4-repressed inflammatory response was not associated with modulated p65 binding at 374 enhancers (XREF_FIG E and 6F)."
29343442
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"Naloxone and methylprednisolone significantly reduced the LPS induced increase in IL-8 concentrations in serum in vivo, and suppressed the activation of NF-kappaB p65 in the lung tissue."
15970107
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"Our data suggest that HMGB1 and LPS stimulation could downregulate the expression NF-kappaB p65 in cytoplasmic protein and increase it in nuclear protein, thus leading to modulation of IL-1beta, IL-10, IFN-gamma, and TGF-beta expression."
28096525
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"Using chromatin immunoprecipitation, we demonstrate that LPS induced RelA recruitment to the ICAM-1 gene promoter is significantly reduced in luteolin treated cells."
15946255
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"Chromatin immunoprecipitation analysis revealed that B. vulgatus and LPS induced RelA recruitment to the IL-6 promoter is inhibited by TGF-beta1 treatment."
12672795
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"Inhibition of LPS induced nuclear localization of p65 by ATF3."
26412238
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"We found that treatment with propofol significantly (p < 0.05) inhibited LPS induced NF-kappaB p65 nuclear translocation (56.7 +/-11.3 with LPS only vs. 17.7 +/-10.1 with LPS + propofol, XREF_FIG)."
21408125
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"Suppression of LPS stimulated NF-kappaB p65 and JNK activation by BPs in macrophages."
24167596
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"Dipyrone and 2,5-dimethylcelecoxib suppressed LPS induced p65 and JNK MAPK (C-Jun N-terminal kinase mitogen activated protein kinase)."
25222785
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"EGFR inhibition promoted LPS stimulated NF-kappaB p65 nuclear translocation (XREF_FIG)."
24391216
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"Chromatin immunoprecipitation assay demonstrated that LPS induced RelA recruitment to the ICAM-1 gene promoter was inhibited by SME."
15996193
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"PDTC Diminished LPS Induced NF-kappaB p65 Activity in the Hippocampus."
27493629
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"Remarkably, total NF-kappaB p65 protein content was significantly reduced by 30% in LPS and IFNgamma stimulated RAW264.7 macrophages treated with MS-275 (XREF_FIG)."
28344354
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"Inhibitory effect of LZ-207 on LPS induced NF-kappaB p65 activation in HCT116 cells."
26023926