IndraLab

Statements

Met-Phe inhibits NLRP3. 3 / 3
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"Recently, He et al. observed that MF inhibited the activation of the NLRP3 inflammasome, which contributed to the nephroprotective effect of MF against sepsis induced acute kidney injury along with its upregulation of Nrf2 15."
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"In addition, MF downregulated the activation of the NLRP3 inflammasome and NF-kappaB as well as the production of inflammatory cytokines, and the expression of Nrf2 and HO-1 was upregulated by MF."
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"Moreover, MF reduced neuroinflammation, inhibited gliosis, and attenuated the activation of P2X7 receptor, TLR4 and MyD88, NLRP3, and NF-kappaB."
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