IndraLab

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"Pretreating cells with 1 mM L-NAME (1 h, 37degreesC) to prevent NO formation abolished the inhibitory effects of CORM-2 (XREF_FIG), which indicates that CO inhibition of hERG requires NO formation."
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"We also investigated the role of NO in CO inhibition of hERG, as NO mediates increases in I NaL by CO in rat cardiac myocytes."
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"The dependence of CO inhibition of hERG on both ROS and NO raised the possibility that CO stimulates formation of peroxynitrite (ONOO -); therefore, we investigated whether CO could generate detectable levels of ONOO - by using the ONOO - -sensitive fluoroprobe, APF."
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"Our findings strongly suggest that CO inhibited hERG via ONOO - -mediated oxidation."
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