IndraLab

Statements

IL1B increases the amount of ITGB8. 4 / 5
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"IL-1beta activates Itgb8 expression by chromatin remodeling and exposure of binding sites for additional transcription factors, and the expression of Itgb8 in different cell types corresponds with the chromatin state of the Itgb8 core promoter."
27481847
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"We have previously shown that the proinflammatory cytokine interleukin-1beta (IL-1beta) increases ITGB8 expression on lung fibroblasts, which increases alphavbeta8 mediated TGF-beta activation in fibrosis and pathologic inflammation."
21878622
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"Here we report the mechanism of increased ITGB8 expression by IL-1beta."
21878622
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"In human lung fibroblasts, IL-1β stimulates the expression of the integrin β8 subunit (ITGB8) which is responsible for the enhanced levels of TGFβ seen in COPD [105] ."
22874820