IndraLab

Statements

USP35 activates ABHD17C. 5 / 5
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"In support of this, we found that USP35 deficiency significantly accelerated ABHD17C degradation in HCC cells (Fig. 4E, F)."
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"Our data also demonstrate that USP35 promotes HCC development by stabilizing ABHD17C and activates the PI3K/AKT pathway.The oncogenic function of USP35 in other cancers has been well characterized."
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"In summary, these results suggest that USP35 may promote HCC development by stabilizing ABHD17C, thereby facilitating tumor progress through the activation of the PI3K/AKT signal cascade."
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"USP35 promotes HCC development by stabilizing ABHD17C and activating the PI3K/AKT signaling pathway."
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"In line with these reports, we found that the PI3K/AKT pathway is disrupted in USP53-deficient HCC cells, which is likely caused by a lack of sufficient ABHD17C.In conclusion, our study provides evidence that USP35 promotes HCC development by stabilizing ABHD17C (Fig. 8)."
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