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"To confirm the observation that the CHMP5 complex in osteoclasts contains the deubiquitinating enzyme USP15 and VCP and p97 (XREF_FIG), the physical interactions between CHMP5, USP15, and VCP and p97 were studied using cell-free immunoprecipitation analysis (XREF_FIG)."

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"Likewise, in osteoclasts the interaction of USP15 with VCP and p97 was markedly decreased in the absence of CHMP5 (XREF_FIG), suggesting that CHMP5 mediates the interaction between USP15 and VCP and p97."