IndraLab

Statements

USP22 activates autophagy. 6 / 7
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"USP22 induced autophagy was also found to enhance cell proliferation and resistance to starvation and chemotherapeutic drugs in Panc-1 cells, therefore expressing an overall effect that promotes cell survival."
25241857
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"In addition, in a pancreatic cancer cell line (Panc-1), USP22 overexpression stimulates autophagy through the ERK1/2 pathway and hereby promotes resistance to gemcitabine treatment [XREF_BIBR]."
29210986
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"USP22 upregulation may thus inhibit apoptosis and stimulate autophagy in response to treatment with DNA damaging agents or targeted inhibitors to promote resistance to chemotherapy in cancer patients."
29210986
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"Beyond regulating apoptosis, the USP22 and SIRT1 pathway may also modulate autophagy."
29210986
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"USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent autophagy."
35900990
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"Taken together, these findings reveal a potential mechanism underlying the chemoresistance of PC cells mediated by the regulation of USP22 mediated autophagy by miR-29c, suggesting potential targets and therapeutic strategies in PC."
29807360