IndraLab

"Finally, USP8 inhibited SQSTM1 degradation and autophagic influx in cells with wild-type SQSTM1, but not its mutant with substitution of K420 with an arginine."

"USP8 or USP9X silencing inhibits ITCH-mediated HER3 degradation induced by the anti-HER3 antibody 9F7-F11."

"While one report suggests that Usp8 inhibits EGFR degradation [25] , we and others have demonstrated that Usp8 promotes EGFR degradation [21,26] ."

"Although EGFR overexpression is not a consistent finding in USP8 mutation positive tumors, in vitro studies have proven that USP8 mutants inhibit the degradation of the ligand-bound EGFR in EGF-stimulated cells. xref , xref Expression of the somatostatin receptor type 5 (SSTR5) and O-6-methylguanine-DNA methyltransferase (MGMT) are increased in USP8 -mutated tumors, suggesting that such tumors might be responsive to the pharmacological treatment with pasireotide, but not with temozolomide. xref The frequency of USP8 mutations is higher in females in all the cohorts reported so far, but there are discrepancies among studies regarding other clinical and biochemical features. xref – xref , xref Interestingly, the frequency of USP8 mutations in a recently reported cohort of patients with Nelson’s syndrome (45%), was not higher than what has been reported for CD, although such mutations were associated with lower frequency of ACTH normalization after surgery. xref "

"While some reports suggest that Usp8 inhibits EGFR degradation [40] , we and others demonstrated that Usp8 stimulates EGFR degradation [41,42] ."