IndraLab

Statements

Clarithromycin inhibits KCNH2. 7 / 8
1 1 | 5
reach
"For example, an SNP (Q9E) in MinK-related peptide 1, the putative β subunit of I , has been shown to increase the potency of hERG block by clarithromycin (Abbott et al., 1999)."
35148401
drugbank
No evidence text available
12873512
ctd
No evidence text available
24052561
reach
"Abbott et al. [67] , in an elegant study, were the first to report that clarithromycin could block HERG K + channels.Recently, Volberg et al. compared several macrolides for their ability to block HER[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15225662
reach
"The results of this study document that both erythromycin and clarithromycin significantly inhibit the HERG potassium current at clinically relevant concentrations."
14674677
reach
"Also worth noting is the exclusion from Pred-hERG AD of 11 hERG blockers including namely clarithromycin, digoxin, epinastine, erythromycin, furosemide, fluvoxamine, mexiletine, perhexiline, procainam[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37468081
reach
"Clarithromycin, roxithromycin and erythromycin) have been shown to inhibit HERG currents ( Volberg et al., 2002 )."
16647758